Which (unrelated) actors could plausibly play close relatives?

OK. Malcolm McDowell in A Clockwork Orange does not look like Mark Hamill.

Ben Affleck should play a young Bruce Springsteen in a biopic.
Matt Le Blanc and Robert Vaughn could play father and son.

Beat me to this pairing.

Bruce Campbell and Nicholas Brendon.

IIRC, the various ethnicities of those characters came from the novel the film was based on. In fact, the backgrounds of the actors didn’t match those of the characters–Connery’s was Irish, Hoffman’s Irish/Sicilian, and Broderick’s half-Jewish.

In the 80’s there was a lot of confusion between Margot Kidder, Karen Allen, and Brooke Adams.

Also, apparently Vanessa Redgrave and Maggie Smith occasionally get mistaken for one another, although I suspect typecasting has something to do with that.

Since Kelsey Grammar’s name keeps popping up, I’d like to nominate him and Robert Picardo, the guy who played the doctor on Star Trek: Voyager. They could play brothers.

Matthew Broderick’s mother is Jewish. He’s been cast in Jewish roles several times, including Neil Simon’s Brighton Beach Memoirs and Biloxi Blues.

Every time I see a thread like this, I’m stunned when no one has mentioned The Rock and Rob Schneider. I would love to see a remake of Twins starring these two, because they really do look like truly fucked-up twins, man.

Recommended reading: “The Hollywood Gene Project” entries under “Blue Moons” on Fametracker.

I agree with Tangent: Hugh Jackman and Clint Eastwood. Also that kid from Home Improvement and Val Kilmer.

How about Frances McDormand as the mother and Emma Caulfield as the daughter?

I always thought that Harrison Ford and Dennis Quaid could play brothers.

Sandra Bullock and Sarah Michelle Gellar both have that (in my opinnion) ugly box-nose thing going on. It is square at the tip.

There was an episode of L.A. Law that played on this, back in the 80s. In this (humorous) story arc, one of the lawyers learns that his deceased father not only played around like crazy, but left a string of illegitimae sons in his lake, all of whom are about the lawyer’s age, and all somewhat resembling him. The lawyer was played by Alan Rachin (he later played Dharma’s dad), who was bald, with a fringe of black hair. He looked then like Dr. Phil today, only thinner.

To pull this off, they basically rounded up every character actor who met this description. One of them was Jeffrey Tambor (Hill Street Blues, The Larry Sanders show). I don’t remember the others, but you would have known them; they weren’t nobodies. There were about six of them in total, all character actors that you would have recognized (at least back then), and once they were all in the same scene, you thought, damn, they DO all look alike!

Bruce Willis and Mickey…uh… from 9 1/2 Weeks? (I’ll remember his name the second I hit "submit, I just know it.)

John Goodman and Norm from Cheers.

Agreed on Redford and Pitt - Pitt’s resemblance to Redford in A River Runs Through It was almost breathtaking.

ROURKE!

(On the very second I hit submit, I swear.)

I didn’t see this, but I can imagine that Herb Edelman was another one.

Oh, one more.

The late Dick Sargent and Ronny Cox. The ironic thing is that either Sargent’s real last name was “Cox,” or Cox’s real last name is “Sargent.”

Luke Wilson, Alec Baldwin, and David Duchovny could play brothers or something… I’ve heard some disagreement on this, though, so maybe it’s just me.

Sean Penn and Adam Storke
Christian Bale and Ethan Hawke
Julia Roberts and Kyra Sedgewick

elfkin477: Funny you should mention Nick Brendon…he actually has a twin brother in real life, who usually works as his stand-in on Buffy. They did an episode with the two of them in the fifth season – it turned out pretty good.

Speaking of Buffy people: Amber Benson could easily play Angelina Jolie’s sister. Actually, if you wanted to have Gwyneth Paltrow and AJ to be sisters, Amber could help make the connection, because she kinda looks like both of them.