The books have to balance. Not at every instant but, when everything is tallied, all of the numbers have to come out right.
There’s a kind of event, or interaction, called beta decay. Actually, there are a few forms of beta decay, and I’ll only talk about one of them, because it’s easier. I’m going to talk about β[sup]−[/sup] decay, which is when a neutron turns into a proton.
A neutron has a charge of zero. A proton has a charge of +1. Now, we know that charge is conserved, which means that it can’t be created or destroyed, which means that if you have zero charge going into the interaction, you have to end up with zero net charge coming out of it. Therefore, β[sup]−[/sup] decay creates an electron, with charge -1. +1-1 = 0. Check.
There is, of course, a further check to this theory: We can observe electrons. They’re charged particles. They make nice little tracks in the bubble chambers because they disturb other charged particles, like the ones in the atoms the gas in the bubble chamber is made from.
There’s another problem: A neutron weighs more than a proton. It isn’t much but, you guessed it, mass is conserved. Mass can be conserved by converting it into energy, but that isn’t happening here. We can detect gamma rays, too, and we aren’t seeing any. Further, nothing’s going fast enough for the extra mass to have been converted into momentum. Therefore, either mass isn’t being conserved or we’re missing something.
Since mass conservation holds absolutely in every other interaction, the smart money was that we were missing something.
So we could predict the properties of the particle we needed: Small, because the missing mass was small, and not electrically charged, because the emission of the electron took care of that, and, besides, we could detect a small electrically charged particle.
We knew it was small for another reason: It wasn’t jostling anything else loose. It had to be small, or else it would have disturbed some atomic nucleus enough to leave evidence of its passing.
Anyway, that takes you up to 1931, when Wolfgang Pauli first hypothesized the existence of what we now call the neutrino. It took until 1956 to actually detect the damned things. Why? They’re small neutral particles, which can pass through bulk matter, like plants or humans or planets, like tiny snowflakes falling through wide mesh: Most of them pass right through and don’t do anything at all. The few which do interact, do so so minutely, it gets lost in the noise of everything else. It requires tons of pure water in deep salt mines to detect the barest fraction of the billions of neutrinos the Sun shoots through us every second.
So that should give you some idea of how we can predict the existence of particles decades before we get to observe them, simply by determining which particles must be necessary and which properties they must have based on our theories. Of course, the theories could be wrong, but keep in mind that every new theory has to make all of the same successful predictions the existing one did, and then some.
Well, that was extremely over-simplified. In fact, it left out a whole particle: The existence of the W[sup]−[/sup] boson is firmly beyond the scope of this post.
http://www.astro.wisc.edu/~larson/Webpage/neutrinos.html