James Reavis, fraudster claimant to the Barony of Arizona, was exposed in part by the mismatch of long s in his forged documents with how it had actually been used.
There’s also the type sorting issue, where the f and long-s get frequently sorted into the wrong bin.
Does anyone remember Cecil Adams?
Youngsters! Feh!
Even plain TeX offers “Roman” (and slanted) versus “Italic” 
There is a typeface named “Zapfino” that includes at least 4 or so variants of each letter, because it is supposed to be inspired by handwriting and calligraphy.
Yes it does. That’s when I first became aware of the difference, even though I had been seeing it forever.