Not really. I don’t think all the nuances of key have been fully worked out, but here are a few things that complicate matters.
A guitar is nominally an equally tempered instrument. In reality it is only an approximation to that (as are pretty much all physically realised instruments - you really can only get exactly right with a synthesiser.) Guitars can never get exactly to equal temperament, and the issues with how it mismatches lead to a range of intonations that suit different styles and needs. Just how you tune a guitar makes a difference. Simple things like tuning up the guitar fretting the fourths yields a different tuning to tuning on the harmonics, which yields a different intonation using an electronic chromatic tuner. Usually all are good enough for rock and roll, but not good enough for many jazz players. (You get things like the Buzz Feiten system, - which if you read the history seems to eventually turn out to be an approximation to Werckmeister temerament.) You can tweak the intonation on a guitar to suit a range of needs, and the compromise is that you always make it worse for some others. Some keys will sound bad, other good. Some positions sound good, others not so good. It will depend upon your needs. But there isn’t any initial base level “right one”.
The question of A 440 is more difficult, as the variations over the years are more about timbre than the actual frequency. The change in pitch over time has been very small really. But the implication for instruments has been much more severe. An instrument constructed for a lower pitch A, will when tuned higher be stressed more, and the partials will move in slightly inharmonic ways that mean the instrument sounds slightly different. The drive to higher pitches in orchestras seems to have all been about making the string sounds cut through with more sizzle. Just the slight rise in pitch isn’t the whole story.
There is some suggestion that we respond to individual notes in different ways. No matter what, the entire octave spans a two to one variation in frequency. If we have some sort of deep intrinsic feeling about notes spanning such a range, there is probably some reason to believe there is an intrinsic emotional/feel attached to the key centre chosen, so that there is some artistic merit in that choice. Something I think that supports this notion is that people can attach colours to individual notes, and there seems to be some consistency in what colours are associated with which notes.
All real instruments have the above mentioned compromises, even instruments that are considered as transposing. Typically even a piano will have a temperament that favours some keys over others. When you are faced with a full orchestra the problems faced with so any instruments that fundamentally can’t transpose and have preferred keys means the key chosen has a lot of implications. Indeed a key may have been chosen because it has a poor match, and thus has a dark, bright, slightly weird feel. But that doesn’t come from the intrinsic nature of the key, but from the intricacies of the various intonations and miss-matches.
No matter what, for reasons I outlined earlier, it is very very hard to get perfect note ratios, and the mismatches all colour the result. These mismatches vary with key, scale and the intonation of the instrument, leading to certain keys having certain colours, on certain instruments. YMMV.