One of the key indicators of stability is the neutron-proton ratio,so taking a stable isotope and adding or taking away a sufficient number of neutrons will create a an unstable isotope.
Yes, this is a fundamental characteristic of the nuclear force. Neutrons are needed in order for the attraction between protons to be stable. If you have too many neutrons or too few, the nucleus is unstable. Since an isotope can have any arbitrary number of neutrons, you can always specify an isotope that is unstable.
Here is an interesting plot. Stable isotopes are shown in black, and isotopes with half-lives too short to have ever been measured are shown in white. Atomic number (Z) is on the bottom, neutron number (N) on the left.
In many ways it’s a very trivial observtion, because if you have an isotope with 500 neutrons in the nucleus, you know it will be incredibly unstable whatever element (though such an isotope would be for all intents and purposes impossible to create).