OK, Moon BASES, that IMO is not so far-fetched, nor would be large permanent manned space stations. But notice I say bases, stations. Purpose-built specific-mission type of activities which may be physically permanent and continuously manned but only insofar as the crew necessary for the mission and most often on a rotating basis – think Wake or Midway islands during the Cold War, or even the current Antarctic bases. Colonies, OTOH, as mentioned in another post upthread are another kettle of fish altogether, and the establishment of a colony would be very much dependent on finding something that makes it worthwhile to actually maintain a resident population, of more than just the actual members of a mining crew/garrison/research team or whatever.
I would not be surprised if before 2100 we do just as much vis-a-vis man-in-Mars as we did with man-on-Moon in the 20th century, based on purely practical cost-benefit aspects, beginning with, and by no means this is the least of them, how getting any large public or corporate project even off the damn drawing board is a pain. Look at all the time, effort and money sunk into design and development for better-than-Shuttle/Soyuz spacecraft and for “real” Space Stations between the 80s and 2000s by the US, EU, the Soviets/Russians, Japan, etc. , and in the end manned spaceflight today is… pretty much where it was 20 years ago, only more expensively. Now, if we manage to really get some major breakthroughs in long-duration propulsion/life support/self-sufficency of systems, Mars could be made a reasonable place to station rotating research expeditions. Colony, though? Viability issues arise again.
In general terms I can see the point, though, of someone like the late Gerry O’Neil who would say that actually colonizing planetary surfaces imposes a steep gravity-well tax, and that if you’re going to have large groups of humans in a situation where they’ll perforce be confined to self-enclosed habitats in an environment that threatens death at every major malfunction, for major parts of their lifetimes, you might as well forget planetary surfaces and just build rotating orbital habitats for them. And even then, you still need a* viable reason * to have them out there, one that you can justify to whoever’s holding the loan – don’t you, really?
Now, I would not sympathize with a position that there can never ever possibly be ANYTHING worth the price-per-pound of large-scale space settlement(*). Yet I can accept that it would likely have to be involve things, processes and market situations that we cannot yet imagine. Now it is true that just because we can’t imagine it, doesn’t mean it won’t ever be discovered, but conversely just because we can imagine it, doesn’t mean it can (never mind must) happen. Of course, even then its mere discovery would be no guarantee that someone will have the epiphany of where you plug it into the flowchart leading to “Profits!” instead of leaving it on the shelf under the heading *“Interesting side-note.” * It is not until WHEN AND IF that particular hypervaluable thing/process IS actually identified and actually given such ultrahigh value, that there’s a reason to go beyond limited-scope exploratory activity into actual colony-building.
(*And I’m not even mentioning nontangible, nonrational “value” – ideological, religious or nationalistic purposes driving a public or corporate entity to build a Space Colony just to prove their point and gloat in their greatness. Heck, wasn’t that one main driver behind the 1960s “Space Race”? Were it up to me I’d just love to create a viable Space Colony just to make the point that it’s possible. “Because It’s There”. But I realize, who am I to make you pay for my aspiration in exchange for nothing **you ** value?)