Short answer?
If it’s serious, no.
If it’s a comedy? Pure gold. 
(The FCC would never approve of it…)
Law & Order: The Swiss Guard
CSI Vatican City (Instead of millions of dollars of forensic equipment, they solve grisly murder cases with faith alone!)
R.O.M.A. Blue (Cardinal Sipowitz, whose fat pasty ass we see a lot of in Season One: “Remember what happened last time you dissed a Polish Cardinal? Lemme stir your memory, dirtbag: It was in 1978. Two weeks later, he was the freakin’ Pope!”)
No sexual tension.
Or at least not the kind that most of America wants to see … .
Are you kidding? Look at all the attention the Michael Jackson trial is getting!
The Pope Dowling I Mysteries!
I think it would be interesting - kind of like Da Vinci Code esque…
Pope Squad. 4 nubile young nuns travel the world fighting crime and rescuing sinners from the clutches of Dr. Abortus, with only the aid of their ninja skills and the sage of advice of Mr. P. Who knew there were so many hot tubs in the Vatican City?
The Saintly Life: Two spoiled Hollywood C-list celebrity blondes (Paris Hilton, Nichole Richie) find out what cloistered life is like, as they don habits and join the Pontiff’s private housekeeping staff…
The Odd Couple: Can two unmarried men share a Papl apartment without driving each other crazy? With Tony Randall as Pope Felix XII, and Jack Klugman as Head Rabbi Eli Krustofsky.
Papal. Papal. PayPal. Pupae.
Ask and ye shall receive…
BBC THREE has dropped a comedy set in the Vatican to avoid offending Catholics.
http://www.bbc.co.uk/comedy/news/2004/09/24/14434.shtml
Good news, from the same link:
Maybe you could have Pope Martinez, like that one show on King of the Hill with the crime-fighting priest? Vaya, con dios! BANG!!!
Hey, how about: the Pope dies, and the cardinals don’t want to tell anyone, so they just prop him up and make it look like he’s still alive-“Weekend at Popey’s!”
OMIGOD.
I’m now going to flip 180 and completely embrace Faith Is Good’s original West Wing/Sci Fi/Historical Drama proposal, if we can just grab one character from comics (where else?) and and slightly tweak his background so he operates from the Vatican to beef up the “Sci-Fi” part (which might better be served by being more ‘supernatural’ than scientific, but WRYB)
Upon reflection, I think the best way to approach this is to do it with muppets.
Make Kermit the Frog Pope.
Fozzie, Swedish Chef, Beaker, Bunsen, Gonzo, et. al. as Cardinals.
Miss Piggy, Janice, et. al. as nuns.
Each week have a well known celebrity guest star. Willem Dafoe, for example, could appear as Jesus. David Bowie would really rawk as teh Devil. Penn and Teller Franciscan monks…
I’m telling you this could be the next big thing.