Would the ozone hole have been discovered if we had never gone to outer space?

This question involves speculation so am posting in IMHO rather than in factual questions. An article I read yesterday about Thomas Midgley Jr., a chemical engineer who pioneered two of the worst air pollutants, leaded gas and freons, has reminded me of something I have been wondering about for a long time.

As I understand ozone depletion was discovered by a NASA satellite in the 1970s, right? Now, suppose hypothetically, that we had never gone into space, including not having artificial satellites of any kind. Likewise suppose that all other technology that we have invented would still have been invented, and that freons (CFCs) and other ozone depleting chemicals would also exist.

Would we ever have discovered the ozone hole? And if so, what technology could have helped us discover it?

Or would we have continued to produce CFCs and ended up destroying the ozone layer, and wondering why suddenly everything is getting sunburned and dying under ultraviolet radation?

And cancer rates would have increased significantly. It may have taken a bit longer to notice, but even without space travel we had high altitude ballons that would have gathered data.