This thread absolutley reminds me of the judge at the chili contest joke. Link for those of you who haven’t read it before. FWIW, I put this up there with Horror of Blimps for laughs, especially if you’ve ever been caught unawares by a particularly fiery pepper.
Something’s not right about that – something that causes blisters IS damaging. The physiological mechanism that brings about the blisters hardly matters.
Neurons get stimulated by capsaicin, and that can trigger a response; the neuron can release chemotactic factors which mobilize various immunomodulators to the area. The response may be nothing other than the sensation of heat, it could be local redness, or some swelling, or papule formation, or it could even cause blistering, and in rare cases can cause full blown tissue necrosis, if the immune system goes all out.
But mostly it doesn’t cause those types of reactions, and the severe reactions are even more rare. Rare enough that topical capsaicin is approved for sale without prescription.
Thanks for the update. Looks like your friend took one for the team, and that sufficed for you.
Any report on whether that was enough Reaper to trigger a soothing wet wipe purchase?