I recently read the book Anatomy of an Epidemic, and found it fascinating. Here are a couplereviews that touch on some key points. Here is the author’s website.
The basic premise of the book is this
First he looks at schizophrenia, and the well-known fact that schizophrenics in developing countries generally have better outcomes than those in developed ones. How can this be? He argues that the very drugs used to treat schizophrenia often have massive irreversible effects on the brain, causing actual brain damage that makes people who may have simply had a single episode- what we might have once called a nervous breakdown- to become disabled for life. The current view is that schizophrenia is always devastating and barely controllable with only continuing use of the most heavy-hitting of drugs. But is this true? He cites a number of studies that say that those who do not use their drugs have better outcomes.
Then he turns to anxiety. Anxiety (and a number of people who probably were not particularly mentally ill) has often been treated with benzodiazepines (Valium, Xanax, and the like.) Time has shown that these are some of the most physically addictive drugs know to man, and the main withdrawal symptom is…increased anxiety. Although many doctors recognize the pitfalls, benzos are still used in “drug cocktails” used to treat various disorders.
Then comes what I see as the real meat of the book- SSRIs. He outlines the history of SSRIs and how they work medically. He concludes they are not targeted drugs “just like insulin for diabetics.” Rather, they cause various broad changes in brain function. They disrupt any number of systems, which may or may not make you feel better for a bit. Of course, he also cites the numerous studies that show SSRIs are not much more effective than placebos, and also the fact that most depression studies are short term enough (three weeks) that they do not record the episodes of depression that resolve themselves without treatment within a month or two.
He points out that in the past, even people who were hospitalized with severe depression were expected to and often did recover. We did not have large groups of people too depressed to work. Now, we consider depression a “chronic disease” requiring continued medication for life. As proof, we are told that people who discontinue their drugs tend to get depressed again. But is this a function of depression or is this a function of the changes the drugs have made to the brain? Depression seems to come immediately after withdrawal. Doesn’t this seem suspicious? Could depression drugs be actually making us more depressed? Are they making what may be a single bout of depression into a chronic life-long disease?
Even when people on medication relapse, we attribute to the idea that “the medication needs to be adjusted” and do not consider that the medication may be contributing to relapses. In short, we know the SSRIs have poor long term outcomes with almost sure relapses. But for some reason we still keep saying that they work as a long-term solution.
He then tackles the alarming rise of bipolar disorders. He looks at how the definitions have changed and broadened, and then at the possibility that SSRIs and other drugs are actually triggering manic episodes, which are then treated with more drugs, which may lead to even more disruptions. We know the drugs used to treat biploar disorder have numerous devastating effects on the body in the long run. Are they also causing devastating effects on the brain?
Finally, he looks at childhood behavior problems, and especially at the way ADHD has an alarming tendency to morph into bipolar disorder. We already know that both stimulants and anti-depressants have the possibility of causing manic episodes. We then treat those manic episodes with long courses of heavy drugs. Could these drugs be causing children to develop chronic mental illness?
Personally, I recognize the value of psychological medication for individuals, and have seen people transformed by them. At the same time, I have chosen to deal with my own problems on my own, with stunning success. I believe that often depression actually does have some underlying cause that can be consciously changed- often just a couple of bad patterns or an unresolved problem that needs to be processed. Drugs may help you get past the hard part, but if you don’t address the problem underneath you are going to keep having problems. I found the book to be quite compelling. We acknowledge that any other drug that acts on the brain- from alcohol to ecstasy- has the chance of causing harmful permanent changes. Drugs prescribed by doctors are no different.