Probably the 1st First Lady to be a college graduate (U of Vermont, 1902)
The First President to have a mother who was a college graduate came much earlier; William Howard Taft’s mother. Louisa Torrey, graduated from one of the first women’s colleges, Mount Holyoke College (then Mount Holyoke Female Seminary) in 1845.
Ronald Reagan - three surviving children and at least two grandkids
John F. Kennedy - one surviving daughter and three grandkids
Barack Obama - two daughters
Harry S Truman - four grandchildren
Jimmy Carter - daughter Amy (b. 1967) and her son Hugo James Wentzel (b. 1999)
John Adams - around 9 great-great-great-great-great-grandchildren, and probably others
Based on the 1997 obituary of Thomas Adams, a great-great-great-grandson, which said that Thomas was survived by a brother, a sister, 4 children and 9 grandchildren
Ronald Reagan - three surviving children and at least two grandkids
John F. Kennedy - one surviving daughter and three grandkids
Barack Obama - two daughters
Harry S Truman - four grandchildren
Jimmy Carter - daughter Amy (b. 1967) and her son Hugo James Wentzel (b. 1999)
John Adams - around 9 great-great-great-great-great-grandchildren, and probably others
Richard Nixon - Tricia Nixon Cox, and her son Christopher Nixon Cox; and others
Dwight D Eisenhower - grandson David Eisenhower, 3 great-grandchildren by David’s wife Julie Nixon, several other grandchildren, great-grands and great-great grands
Ronald Reagan - three surviving children and at least two grandkids
John F. Kennedy - one surviving daughter and three grandkids
Barack Obama - two daughters
Harry S Truman - four grandchildren
Jimmy Carter - daughter Amy (b. 1967) and her son Hugo James Wentzel (b. 1999)
John Adams - around 9 great-great-great-great-great-grandchildren, and probably others
Richard Nixon - Tricia Nixon Cox, and her son Christopher Nixon Cox; and others
Dwight D Eisenhower - grandson David Eisenhower, 3 great-grandchildren by David’s wife Julie Nixon, several other grandchildren, great-grands and great-great grands
Gerald Ford - three sons, one daughter, grandchildren