It’s ironic that one of the things that makes race so hard to discuss is that there is no firm definition of race, but one of the things that makes this particular conversation so difficult is that there is also no firm definition of “biologically meaningful”. Here are a variety of different ways one might define “biologically meaningful”, as it applies to ways-to-group-human-beings:
(1) A set of groups is “biologically meaningful” if brilliant but naive scientists (ie, aliens who come to study human biology and have zero knowledge of or interest in earth culture) would arrive at these (or nearly identical) groupings totally on their own. For instance, they would almost certainly come up with an idea of male vs female that almost precisely matched our own.
(2) A set of groups is “biologically meaningful” if brilliant but naive scientists would come up with a set of groupings which, while clearly different from ours, would have at least some commonality… that is, elements in the same group in our system would be more likely than pure chance to be in the same group in their system. For instance, we might divide people into children, adolescents and adults, while the alien scientists would divide by various other age-related criteria. So the groups would be different, but clearly related.
(3) A set of groups is “biologically meaningful” if we could take those groups, present them as fait accompli to brilliant but naive scientists, and those scientists, using purely biological/genetic factors, would then be able to perfectly measure and define those groups, and sort further individuals into those groups with near-perfect precision.
(4) A set of groups is “biologically meaningful” if we could take those groups, present them as fait accompli to brilliant but naive scientists, and those scientists, using purely biological/genetic factors, would be able to sort further individuals into those groups… not perfectly, but better than pure chance would dictate. (For instance, “I have divided people into groups based on the last digit of their social security number” would presumably fail this test.)
(5) A set of groups is “biologically meaningful” if scientists would active seek information about these groupings while doing various science-y things. For instance, scientists doing large survey health research would almost certainly want to get information about the age and gender of the various subject being studied. Would the scientists spontaneously say “hey, it would be very helpful if we also had grouping-data-X for each of our subjects”? If so, then it’s biologically meaningful.
(6) A set of groups is “biologically meaningful” if scientists who were studying large numbers of people while doing various science-y things might not spontaneously think to ask for this piece of grouping information, but, if they were presented with this grouping information already-existing, would ever possibly find any scientific use for it. (Ie, scientists might not spontaneously ask “hey, which of the ill-defined and socially constructed racial groups does each subject fall into”, but if they happened to have that data along with their information, might notice “hey, people who self-identify as Asian have a higher incidence of condition X, that probably bears further investigation”.)
Now, do I think that race passes any of those tests? I think it likely passes 4, almost certainly passes 6, and possibly passes 2 (note that those are the weaker versions of 3, 5 and 1, respectively). But my point is not to make some positive claim about the usefulness of race. My point is that if you’re making the claim that race is 100% biologically meaningless, then you’re making the fairly extraordinary claim that not only does it not meet any of those 6 criteria I just listed, it also doesn’t meet any other similar such criteria. Unless, that is, you can prove that there is a single well-understood well-defined definition for “biologically meaningful”, which I’m skeptical of.