It’s a judgement call. Any work of fiction is depicting something other than the real world. There’s no hospital in our world named Seattle Grace but I don’t think many people feel that Grey’s Anatomy is set in some alternate universe. We just accept that it’s our world with some fictional characters and elements added.
So I put the AI’s in Questionable Content alongside Snoopy or Spiderman or the Addams family. Even though none of these characters could exist in the actual real world, I feel the settings they are in are a fictional version of our real world.
On a separate note, I don’t think Pixie Trix is set in a world with magic. Lagace and Lumsdon essentially have two settings for their stories; Menage a 3, Sandra on the Rocks, Sticky Dilly Buns, and Pixie Trix are set in a non-magical world while Eerie Cuties, Dangerously Chloe, and Magick Chicks are set in a world that has magic. (I didn’t read Penny and Aggie so I don’t know where it fits in.)
