Coronavirus COVID-19 (2019-nCoV) Thread - 2021 Breaking News

I’m not sure there are any established religions that actually oppose vaccination.

The Christian Scientists are ambivalent:

For more than a century, our denomination has counseled respect for public health authorities and conscientious obedience to the laws of the land, including those requiring vaccination. Christian Scientists report suspected communicable disease, obey quarantines, and strive to cooperate with measures considered necessary by public health officials. We see this as a matter of basic Golden Rule ethics and New Testament love.

As for the issue of exemptions for vaccination in the law, Christian Scientists’ perspective on this issue may be unique. In the past, many public officials have been broadly supportive of exemptions when these have not been considered a danger to the wider community. In more recent years, public health concerns relating to vaccinations have risen as exemptions from them have been claimed by larger numbers. Christian Scientists recognize the seriousness of these concerns.

Most of our church members normally rely on prayer for healing. It’s a deeply considered spiritual practice and way of life that has meant a lot to us over the years. So we’ve appreciated vaccination exemptions and sought to use them conscientiously and responsibly, when they have been granted.

There have been a lot of cases in the news recently about groups of Orthodox Jews avoiding vaccines, but that’s not because there’s anything in Judaism against vaccines, it’s just been cases of a somewhat isolated community not trusting outsiders.

Seventh Day Adventists avoid blood transfusions, but they are apparently okay with vaccination

https://www.adventistreview.org/2106-40

an article in the December 18, 2020, edition of the Adventist Review entitled “COVID-19 Vaccines: Addressing Concerns, Offering Counsel.”4 The church’s official declaration on immunization “places strong emphasis on health and well-being. The Adventist health emphasis is based on biblical revelation, the inspired writings of E. G. White (cofounder of the church), and on peer-reviewed scientific literature.” A “responsible” attitude to immunization/vaccination is urged, advising that “no religious or faith-based reason” exists for avoiding “protective and preventive immunization programs.” The statement goes on to emphasize both the importance of community health and of individual conscience: “We value the health and safety of the population, which includes the maintenance of ‘herd immunity.’

I think the religious thing is something of a red herring. I think the people who have legitimate reasons to avoid the vaccine are mostly people who either have an allergy or who had a bad reaction to their first dose. I know a couple of people in that category. One had an ordinary allergic reaction. The other one suffered debilitating dizziness for weeks after vaccination, and even if it was just a weird coincidence, I don’t want to be the person forcing him to try it again.

All had mild or no symptoms. This will be interesting as the weeks go by.

And the vaccination rate on that ship, passengers and crew, is 95%+

“Welcome aboard the SS Petri Dish”

Now they did:

Who Needs an Additional COVID-19 Vaccine?

I rather expected for my condition to be on the list, based on two smallish studies, but it is not.

The advisory committee recommended a clearer statement than I see of who should NOT get a booster at this time. As with the broader mess, I suspect a lot of people who should be top of the list will refuse, as others with no evidence based reason for a third dose rush in.

A lot of conservative religious folks oppose vaccines (or anything else) that are made in some way with tissues from aborted babies. But that’s an abortion thing, not specifically a vaccine thing.

https://www.sciencemag.org/news/2020/06/abortion-opponents-protest-covid-19-vaccines-use-fetal-cells

Since then, the pope has come out in favor of vaccination. Those fetuses were aborted decades ago, and for the mRNA vaccine, the only connection between the vaccines and the fetal cells lines was some early testing.

Those folks will need to forgo all modern medicine then. HEK-293 cells are so commonly used, pretty much everyone in biomedical research and drug discovery/scale-up uses them.

206,974,880 total cases
4,358,471 dead
185,599,212 recovered

In the US:

37,364,700 total cases
637,161 dead
30,130,092 recovered

Yesterday’s numbers for comparison:

Jesus, >150k cases a day in the US. :sweat:

I’m fairly certain this isn’t pay-walled, but no promises. According to Banner Health (the largest health system in AZ and the first to defy laws against mask mandates and mandatory vaccination for employees), the number of children hospitalized for COVID doubled in July.

When I clicked the above, it mentioned I had X number of free articles, so it might get paywalled. Just in case, I’ll quote the three paragraphs I think are most telling (besides that quoted in the infobox)

Of particular concern is that children ages 11 and younger are not yet eligible to get the vaccine and it could be mid-winter before the vaccine is approved for use by that age group, pediatric experts say. So far, a vast majority of COVID-19 positive patients who have been hospitalized and died since the highly contagious delta variant recently took hold in the U.S. were unvaccinated.

Banner Health, Arizona’s largest health care system, admitted 71 COVID-19 positive pediatric patients in July, which was double the number it admitted in June, Banner’s chief clinical officer Dr. Marjorie Bessel said during a briefing this week.

The number of pediatric patients hospitalized within the Banner system in Arizona is close to what it was in the October 2020, when 77 COVID-19 pediatric patients were admitted to Banner hospitals in Arizona, the company’s data shows.

They also mention that the reason this is worrying is due to the spikes in pediatric cases in other states, like Louisiana, Florida, and Texas, along with an out-of-season spike in respiratory illness in children in general.

I was thinking, hoping that some states would put the pause on reopening in-person learning but that is obviously not happening, and unfortunately, that might drag surge by a few more weeks, and it’s going to result in dead children. The thing that burns my ass is that this just doesn’t have to happen - but it will…

Israel’s Pfizer efficacy data appears to be corroborated, at least in the United States.

It found Pfizer’s effectiveness dropped to 42% in Minnesota in July, when Delta became dominant

This is in terms of stopping transmission and infection; it still seems pretty good at stopping worst outcomes, which is also what Israel found.

During that month in Minnesota, Pfizer’s effectiveness against COVID-19 infection dropped to 42%, while Moderna’s dropped less dramatically to 76%.

An unnamed senior Biden official told of the study: “If that’s not a wakeup call, I don’t know what is.”

I think there we are leaning in that direction, but we still need a lot more work to nail down the numbers. Did you see the range of possibilities?

Pfizer was at 42%, 95% CI: 13-62%, which is not terribly precise.

The data also has to be analyzed for confounding factors such as age, comorbities, time since vaccination. I don’t see that a blanked “42%” is all that meaningful.

The paper has the same demographics per vaccine. However, the ages skew toward +65.

Since both cohorts skew older, it doesn’t explain why the Moderna is working better than the Pfizer. The authors say this (note the dosing differences):

BNT162b2 is administered as 30μg/0.3mL (100 μg/mL) doses 21 days apart20 and the Moderna vaccine is administered as 100μg/0.5mL (200 μg/mL) doses 28 days apart.21 Assuming similar sized constructs, this means that each mRNA-1273 dose provides three times more mRNA copies of the Spike protein than BNT162b2, which could result in more effective priming of the immune response. There has not been a head-to-head comparison of the neutralizing antibody titers elicited by BNT162b2 versus mRNA-1273, but such a study could provide important context for our results. Certain adverse effects, such as myalgia and arthralgia, were observed more frequently after vaccination with mRNA-1273 than BNT162b2 in their respective clinical trials, and it can be speculated that this increased reactogenicity is paralleled by increased immunogenicity.3,4 Furthermore, there are differences in the lipid composition of the nanoparticles used for packaging the mRNA content of mRNA-1273 and BNT162b2. BNT162b2 has a lipid nanoparticle composed of ALC-0315, ALC-0159, distearolyphosphatidycholine (DSPC), and cholesterol whereas the lipid nanoparticle of mRNA-1273 is composed of SM-102, PEG-DMG, DSPC, and cholesterol.22 The structures of the cationic lipids (ALC-0315 and SM-102) in each formulation are shown in Figure S5 .

None vaccinated. :woman_facepalming:t4:

Are schools going to turn into superspreader events?

How could they not? Vaccination rates in the 5–18 set are abysmal (largely because 5–12 cannot be vaccinated), Delta has a high R0 and is circulating widely, and also seems to affect fully vaccinated people more than never, who may themselves be able to spread it.

That’s the best-case scenario, and I only say that because I haven’t seen good, reliable numbers on how Delta spreads among the fully vaccinated.

Today for the first time I can recall ALL of the states on the Johns Hopkins Coronavirus “Data Visualization” map show the states in various stages of red, meaning that the seven-day-average reported new cases is going UP in every state (and the District of Columbia, and Puerto Rico). Even at the times of roughest infections in the past it seemed as if a couple of states were in the blue, without increasing rates.

There are record new highs in

Mississippi (4600)

Louisiana (8175)

Florida (37,941 !!!)

Hawaii (656)

Oregon (2313)

Washington (3731)

and other states look awfully close – Georgia, Kentucky, Puerto Rico, North and South Carolina, Texas, and Kansas, with lots of other state sharply increasing.

The US as a whole is heading toward a new record high