USURY (US+ury)
++++
That confused old nag I rely on is much better than a young horse.(8)
YEARLING (nag I rely*)
+++++
Doubleplusgood party (6)
INGSOC (1984 doubleref)
++++++
Salmon with your Coke? Yes, please! (7)
SOCKEYE (anagram)
+++++
“I whip” heard the lens protector. (7)
EYELASH (I lash)
That sound rattles associate bard. (11)
SHAKESPEARE (shakes peer)
+++++
Break about revenge (7)
RESPITE (RE spite)
+++++
Something brought it back that I made his acquaintance (4)
ITEM (I + met reversed)
+++++
I try and meet a mixture of goals with confidence (8)
Emanated?
Not quite what I was going for, but a fair effort. Think of the “and” in the clue more as a plus sign.
OK, I thought it could be an anagram, and a synonym of “with confidence,” but that’s the wrong direction apparently. 
TEMERITY (anagram)
++++
Jewish school destruction is heavy.(7)
Right direction, just missed the final turn! Admittedly it’s not my best clue - a couple of extraneous words obscured it too much, I think.
YESHIVA (is heavy*)
+++++
Opening of book without the monologues (6)
the VAGINA monologues
(although I consider it more of a play than a book)
++++++++++++++++++++
I’ve seen inside the messed up head of nasty restless people (7)
Natives?
Yes. the natives are restless. NAT-ive-S where NATS is the start of nasty mixed up.
Of course. I was thrown off by the “start of” part, which usually means the first letter of the following words. I totally forgot about the expression. Good one!
Playing off NATIVES
Bestow I the messed-up grease job in lobby. (9)
VESTIBULE (vest+I+“messed up” lube)
+++++
Big aliens support LGBTQ community (7)
Big aliens support LGBTQ community (7)
LESBIAN (aliens* +b)
+++++
Unsophisticated Nigel hating Florence. (11)
NIGHTINGALE (anagram)
+++++
Clean her up! Then you can have a Sprite.(10)