Abandoned mine taken over by single Indian.(8)
SEMINOLE (S mine* OLE) asterisk means anagram
…
Famous person’s foot? (6)
LEGEND (leg end)
Insert upper limb into orientation, then lop off the end to make a French cop. (8)
GENDARME
(GEND + arm + ER, lop off the last R)
Lorenzo, my prescription isn’t nearly enough. (6)
MEDICI (Medicine - NE)
+++++
Crucial problem at the end of war for flyer.(8)
CIRCULAR (anagram “crucial + r”)
+++++
When gathering fruit amid the brambles, if you manage a gauche berry tally, you’ll “Git ‘er done.” (5, 3, 5, 3)
LARRY THE CABLE GUY (anagram of “gauche berry tally”)
++++
No lady, a different lady!(7)
YOLANDA (“No lady a” anagram)
That electronic duo is absurd, you hoodlum. (4, 4)
DAFT PUNK
+++++
The top of the arch that is Pennsylvania. (8)
Keystone
++++
Calls out former allegations (8)
EXCLAIMS (double meaning)
++++
Lisa’s design gets Virginia to drool.(6)
SALIVA (Lisa’s + V)
Old Dominion general turns out to be a bum. (7)
VAGRANT
+++++
Variable power (3)
…TAU?
No, but you seem to be on the right track.
…NTH?
Well done. Take it away!
I actually think 3-letter answers are much harder to get right.
Thanos: “Om dies horribly” to inventor. (6, 6)
THOMAS EDISON (anagram of “Thanos Om dies”)
++++
The sorceror from Rome can reckon on it not being OK.(11)
Word. I don’t mind admitting that I was somewhat fiendishly proud of that one. 
Nocromancer (anagram ROME CAN RECKON - OK)
++++
Cheesy toast is a singular act (7)