Sort of and only on a small, local scale.
The media does not have so much a true anti-Catholic bias as a tendency to treat any large organization as a good target. As a really big organization (that has an international aspect, a national aspect, and hundreds of state and local aspects), the RCC makes an excellent target for all kinds of stories.
Given that the church feels an obligation to speak out on issues of ethics and public policy, that makes it even more of a target (either as an example of interference or as an example of hypocrisy).
In addition, on several areas of public discussion, the RCC is at odds with the direction that public opinion has moved (notably abortion and contraception, but also the death penalty and attitudes toward other public issues), so it is easy to portray the RCC as being “opposed” to “the will of the people.”
I would say that the amount of discrimination that Catholics face, today, is no greater than that faced by any other identifiable group. It clearly happens, on occasion, but it no longer prevents the vast majority of Catholics from getting jobs or promotions or buying houses. (After John Kennedy was elected president, my dad said that some progress had been made, but it was after Cole became the CEO of Gneral Motors and was succeeded by Gerstenberg that my dad figured that Catholics could do anything in this country.)
There has been discrimination. Each of the two parishes where I grew up had to go through an intermediary to buy the land for their churches, because no one in those Michigan towns would sell property to the church (1920s and 1930s). I certainly know people in my lifetime (but not in the last 30 years) who have been denied jobs or promotions because they were Catholic. I can recall the point system for buying houses in which Catholics were rated much lower than their Protestant fellow applicants (although quite a bit higher than Jews). More recently, some Fundie congresscritters directly blocked the appointment of a Catholic priest to the job of congressional chaplain, simply on the basis that he was Catholic. (Having a chaplain may be a violation of the separation of church and state, but it is still discrimination to claim that only the “right” people can attain the job.)
I have also known and worked with people who do not believe that Catholics are good citizens and I have known Catholics who encountered direct discrimination after moving to a few specific regions in the South. (For all I know, the people in those places might discriminate equally against people from the “wrong” Protestant denomination, but I have not done a careful survey to discover that.)
One outfit that is constantly looking for anti-Catholic discrimination, (to the point where they often find it when it does not exist), is the Catholic League. If you go through their web site, you will find a lot of shrill cries where they take offense at things that any intelligent person would either ignore or dismiss as trivial. However, they do, indeed, document some cases of direct anti-Catholic bias in reporting and discrimination in policy.