Literally everything the government does denies liberty to some degree. That’s what it means to have a group of people who get together and make decisions about your life. It varies in degree from a bagel breakfast among congressmen paid for by your tax dollars all the way to arresting people for the chemical they decide to put in their bodies. Unless you deny government altogether, the question is just where to draw the line.
Is self-defense so essential a liberty as to be untouchable? Clearly not. There are plenty of things that could be done in the name of self-defense that people of goodwill of all political stripes find unacceptable. Is having a gun in the home for self-defense untouchable? Maybe it is. In a big, complex society, we have to draw difficult lines. And not just on this issue. We do it with drug laws, abortion laws, roving wiretaps, campaign finance, death penalty, tax rates, consumer regulation, environmental law, etc. Self-defense is one of the hundreds of important liberties in our lives that must be carefully balanced against everything else.
And we would do that careful balancing more effectively, in my opinion, if we didn’t frame every issue as tyranny vs. liberty. Tyranny vs. liberty is an appropriate framework for discussions of things like whether or not we should have universal suffrage, an independent judiciary, or slavery. It is not the appropriate framework for discussing whether someone should be able to smoke pot for their cancer, get a third trimester abortion, carry a .45, or donate thousands to a political candidate. Not that bodily autonomy, self-defense, and free speech aren’t important - they are extremely important and worth fighting for - but the line between tyranny and liberty is not, I’m quite sure, somewhere between Alabama and California. It’s somewhere between Alabama and Iran (or California and Iran, depending on your perspective). And I think if we remember that, and discuss these issues by acknowledging the complexity involved and without shrouding ourselves in the Declaration of Independence every time someone disagrees, we would be better off.