Someone in the hero thread mentioned it, so here goes. (Let’s leave it open to all fiction, literature, everything, yes?) I guess the only real problem here is that supervillains typically do not play well with others.
The Brains: Professor Moriarty, of Sherlock Holmes fame. Managed to have all the crime in London under his personal sway, from the flashiest murders to the lowliest pickpocketing and ruffianry. Also a mathematician of the first rank, and possessed of not unimpressive physical strength.
Hired Gun: Kraven the Hunter, Amazing Spider-Man. Lots of neat gadgets, cool goatee, impressive aim, jungle herbs and potions. I just like him. Also, he managed to impersonate Spidey for a while, which is pretty difficult.
The Financing: L. Bob Rife, from Snow Crash. Sort of a cross between Bill Gates, Ted Turner, and Jerry Falwell. He controls all the media transmission in the world, owns the framework of the Internet, and is branching out to become his own demigod. Does most of his work out of his personal nuclear-powered aircraft carrier while having his mustache waxed.
Provider of the Evil Army: Queen Malformed-Festering-Bloated-Sweaty-Puss Filled-Slug-for-a-Butt, Earthworm Jim. She has an army of lethal humanoid insects willing to die at her merest whim, plus she gets a lot of good lines. Also, it’s my list.
Complete Wild Card: Jeff, from Scud - The Disposable Assassin. A demon that is practically indestructible and has the power to assimilate just about anything to change her form. Turning Jeff loose on anyone mortal is the end for them!
I know this is a strange list, but it’s my OP. Feel free to make your own suggestions.