Angela Bassett
Victor Borge had a nickname of The Great Dane.
Savannah Guthrie
Christopher Cockerell
For a long while, the only psychiatrist who could deal with Adrian Monk was played by Stanley Kamel.
If Mutt is the name of an animal then “Mutt” Lange is another. He’s a music producer, writer and husband of Shania Twain,
(I searched for “mutt” in the thread and there is “burpo the wonder mutt”, but famous here probably doesn’t count)