Its gotta be the Death of Diskworld. I mean what other death would ever wear leather robes and ride a motorcycle when his white horse was unavailable or tell knock-knock jokes to lighten up the moment a bit.
…But I didn’t have the salmon mousse…
Hmm, I like him best in Good Omens, by Terry Pratchett and Neil Gaiman. (Wherever those two go, Death is close behind… >.>) That particular Death is quite similar to Pratchett’s, but just a little more professional, in my opinion.
Zane and the Pratchett standby get honorable mentions. I have read the Neil Gaiman novel linked to up there, but am not very familiar with his works… everywhere I’ve gone, graphic novels are a ripoff, so I don’t buy them without a whole lot of conviction.
By the way, hi. Glad to be here. 
Discworld’s Death, and his little buddy, the Death of Mice.
Personally, I am Death of Chocolate. Any chocolate, in my presence, is a goner.
Obviously Katey Segal as Death from that one episode of “Married, With Children.”
“I could look like your greatest fantasy, or your worst nightmare. I could look like MY worst nightmare, but who’d want to look like Sally Struthers?”
Poe’s Death (I don’t know if this really counts, I mean the Masque of Red Death - Death… since he may just be representative of the plague & not death in general)
SQUEAK.
Gaiman’s graphic novels are NOT ripoffs. They are carefully crafted stories. Gaiman is above all a storyteller, and I don’t believe that he’d allow his stories to be defiled.
Greg of Conker’s Bad Fur Day (N64). He has a hilarious role with humerous quirks such as hating cats and a pip-squeak voice (remedied by a microphone…which broke)
“Bloody cats, they meow and piss everywhere. And their shit just smells bloody awful”.
Please elaborate.
Oops, I meant ripoff in the financial sense. It’s not Gaiman’s fault, anyway, and probably not all the publisher’s either… but it really sucks when you pay almost $20 for a paperback and it starts falling apart after the fifth read.
Definately the Pratchett Death. Amusing, but somewhat less silly than the other ones I’ve seen. THE CAPTIAL LETTERS ARE A PLUS TOO, though I’m not too sure why. They just are.
Oh. Yeah, I know precisely what you mean. My copies have stood up to numerous rereadings, and I am NOT gentle with my books. However, I am not so rough with my reading materials that a book should fall apart on its first reading, either, as has happened with a few mass-market paperbacks I’ve owned. Grrrr.
And, of course, the appearance of Death’s Mother in that same episode. I pretty much nearly wet myself laughing.
Heh. Thought I would chime in with one of the lesser known personifications: Orpheus’s Death in Cocteau’s film Orphée (1949). A beautiful, chilling femme fatale who can walk through mirrors and ultimately sacrifices herself for the man she loves – she’s wonderful.
Manuel Calavera, from the computer game Grim Fandango. He is one of many “Death’s” who work for the DOD (Department of Death), and he is absolutely hilarious!
“My scythe. I like to keep it next to where my heart used to be.”
That’s the Death of Rats in Discworld. 
Yup, Pretchatt’s Death gets my first vote too - he even got a whole book about him.
Anthony’s Death gets the honourable mention.
I wanted to post something about Jessica Lange in All That Jazz; man, did I have a death wish after seeing that. But when I went to IMDB to check some incidental facts about the movie, I saw her character listed in the credits as “Angelique” and described in a plot summary as a muse, so I guess my answer has to be, I don’t know.
However, I will increase the geekiness of this thread by bringing Monty Python into it; specifically, the crabby Grim Reaper (a.k.a. Mr. Death, one of the little men from the village) in The Meaning of Life.
Sir Cedric Hardwicke (you remember him as Ramses the Elder in the Ten Commandments), who gets chased up an apple tree by Lionel Barrymore in “On Borrowed Time.”
Claude Raines in “Here Comes Mr. Jordan.”
TWDuke, I agree that Jessica was Death in All That Jazz. Roy Scheider’s character made several references to dying, death, and the afterlife that she was going to play a prominent part, so I think she qualifies. And, rowr. Almost made me want to abuse drugs if I got to hang around with a lady like that in my hallucinations.
However, I also liked Death from Gaiman’s novels. I liked the issue of The Hulk where Rick and Marly got married, and Death was at the wedding, and Marly (who had been dead briefly) couldn’t figure out where they’d met…