Larry Niven’s science fiction novel ‘Protector’ had an interesting interpretation of this bit of Genesis. In it humanity originally had three life stages, child, breeder, and protector. The breeder stage was pretty much homo erectus, but when they got older certain physiological changes would begin, and the breeder would have the instinctual compulsion to eat the roots of a certain plant, which would trigger a transformation where the brain would expand drastically, the joints would expand (to create greater leverage to increase strength), the teeth would fall out and be replaced by beak-like hardened gums (well suited for their new diet, which consisted solely of the roots of that plant), the genitals would shrivel up and a second heart would develop in the groin, and the person’s skin would get wrinkled and tough enough to turn a copper blade. After transformation to the protector stage the being was far more intelligent than a modern human and would live until killed violently. They also had a strong instinctual drive to protect the breeders related to them and kill those that were different. Their homeworld was in a constant state of warfare as these supergeniuses were constantly fighting each other for territory for their breeders to live on and as they tried to exterminate each other’s breeders (if all of a Protector’s relatives die, then they almost always stop eating and die themselves). This instinct drastically slowed their evolution, as any breeder that was slightly different from it’s relatives was killed.
Anyway, a group of Protectors that had lost their breeders figured out they could keep their will to live by transferring their protective instinct to the race as a whole. They build a colony ship to settle a world towards the edge of the galaxy, freeze a few thousand breeders, and head out. They set up a colony but soon learn that the plant they depend on won’t grow properly there. The Protectors all die out, and the breeders are left to, well, breed.
Over a couple million years the breeders evolved to become more intelligent, though not as intelligent as the Protector stage. When they get to the age where they should transform to Protectors they feel restless, wanting the root but not knowing what they want. They even go part way through the transfomation without the root, but it doesn’t make them stronger, only weaker - the skin wrinkles but does not harden, the teeth fall out but the gums don’t develop into a beak, the joints swell but the muscles and tendons don’t adapt to the changes, the genitals lose functionality but the second heart never develops there, so they develop circulation problems. They are modern humans.
In the story a Protector on their homeworld finds records of the colony ship that disappeared 2 million years before and realizes what must have happened (he has isolated the chemical that is needed for the root to grow, and knows that it is only common near the center of the galaxy). He decides to go see if any of the breeders survive and ‘rescue’ them. This leads to some serious problems.
It’s one of my favorite Niven books, even though there are a ton of holes you can pick in it, it has some really interesting ideas and is told very well. I highly recomend it.