SAM-e contributes to the synthesis and breakdown of serotonin and dopamine, brain chemicals that regulate moods. At least 40 clinical studies offer some support for its use as an antidepressant. More research is needed. (Consumers Report, October 1999)
The most important problem is that SAM is converted into homocysteine in the body, high levels of which may contribute to heart disease (U.of Cal., Berkeley, Wellness Letter, January 2000).