Dr. Clayton Forrester?
Easy one, I think:
She has a smile like the Mississippi River.
.
I also immediately thought Christopher Walken.
Peculiar and hand gestures: Charlie Sheen?
Also, the OP specified looks, which is wicked hard. Except for one like this:
she has a horse-like face, and straggling blond hair.
Red head. Boy? Girl?
No, but I just realized that BUG-eyed is a really good clue.
Christopher Lloyd.
Julia Sweeney?
Probably too obscure, but it should have read:
An actor, somewhat short, grayish/whitish hair, authoritarian voice, often seen in roles wearing a white lab coat.
Michael Richards?
Jerry Seinfeld!
Not Julia Sweeney. One more clue: David Bowie?
Tilda Swinton
I immediately thought Hunter S. Thompson.
there are a lot of perculiar actors!
yeah but whatever is fun. 
he is aged and dignified with a beard and moles(?) on his face below his eyes.
oh and Michael Jackson is correct.
Doesn’t have much gray hair in that photo though.
Steve Buscemi ?
Buscemi is bug-eyed, but nobody guessed it yet. Would it help if I added swarthy?
Morgan Freeman ?
Long shot here but is it Victor Wong?
http://www.allstarpics.net/pic-gallery/victor-wong-pics.htm
Apparently he hates Jews and loves alcohol.