The first portion of the story takes place on a fictitious airplane (IIRC, it was a sorta futuristic overgrown 747).
The protagonist is a company pilot who’s riding as a passenger to his destination. The plane suffers a catastrophic decompression while protagonist is in the john. The author produces a situation where the acting pilots’ backup air supply fails after they’ve instructed the autopilot to descend (I forget the details).
Due to some problem, the plane descends more slowly than desired and the pax and pilots are oxygen-deprived to such an extent that they are all rendered drooling and incoherent. Meanwhile, due to the inward opening-nature of the bathroom door, our hero has had enough air to avoid brain damage (the remaining pressure in the bathroom kept the door shut). When he awakens, he finds himself in a slowly descending, unpiloted airplane full of dangerous zombies. The story continues with him trying to evade 500 unpredictable and frequently violent people as he makes his way to the front in hopes of gaining control (before hitting the ground).
I read this a looong time ago; And it’s quite possible I have a lot of the details either wrong, or maybe confused with other novels. But does anybody remember reading a book similar to this? I’d like to find it again and finish it. I has no idea of the book, or the author’s name.
Sorry about the length of this description.