Hexachalorophene

[galen]

What ever became of hexachlorophene toothpaste? It was highly promoted in the sixties.

[Trout_Mask_Replica]

The FDA restricted the use of hexachlorophene in 1972 because of its reported toxic side effects, which were particularly severe in infants.

Section of the Code of Federal Regulations dealing specifically with hexachlorophene

TMR
If you believed in yourself, and tore enough holes
in your pants, there was always a mist-filled alley
right around the corner.

[abderian]

I don’t recall a hexachlorophene toothpaste, but I do recall the use of hexachlorophene in PhisoHex soap. If I recall correctly, hexachlorophene as an antibacterial ingredient was pulled off the Over-The-Counter market due to the horrible things it’s usage did to white rats.

Here’s this: http://www.macmillan-reference.co.uk/Science/DictionaryofToxicSA-02.htm

hexachlorophene (2,2’ - methylene bis [3,4,6 - trichlorophenol]; 2,2 - dihydroxy - 3,3,5,5,6,6 - hexachlorodiphenylmethane) CAS number 70-30-4. An antibacterial that is used chiefly in the manufacture of germicidal soaps (Phisohex). It is the product of 2,4,5-trichlorophenol plus formaldehyde in the presence of sulfuric acid. Hexachlorophene is a poloychlorinated bis-phenol that in large doses is neurotoxic in animals, presumably due to its effects on brain and spinal cord myelin. Hexachlorophene exerts is antibacterial action by, at low
concentrations, inhibiting the bacterial electron transport chain, and, at high
concentrations, disrupting bacterial membranes. The phenol coefficient (calculated
by dividing the minimal inhibitory concentration of an antiseptic against a standard bacterium by that of phenol) is about 125. Hexachlorophene has greater efficacy against gram-positive bacteria than gram-negative bacteria. Hexachlorophene can
be toxic and, in some cases, fatal when applied repeatedly to the skin, particularly
in infants. Confusion, lethargy and convulsions may occur, as well as diffuse status spongiosus of the reticular formation. Tetratogenic effects have been reported in pregnant nurses routinely using hexachlorophene. Hexachlorophene is used by
health care personnel in washing and in preparing the skin of surgical patients.
Because of potential neurotoxicity, it is no longer commonly used in nursuries.

[C_K_Dexter_Haven]

So that damn jingle about “It’s got hexa-hexa-hexa-chlorophene” that sometimes whollops my brain cells… Can I sue?

[DSYoungEsq]

(giggling) Dex, if you can sue for that, I’m gonna really get that stupid purple dinosaur!