Dr. Gregory House is the alpha and the omega of this concept! His name need not even be mentioned, it’s a given that he’s hot, but undateable.
I was going to say Kelly Bundy, too!
If I was a teenage anime cartoon girl, I would lust after James of Team Rocket. But there are problems - what IS his relationship with Jessie? Is he perhaps…gay? And he spends all that time and money (with Jessie) running after that yellow football, Pikachu, like it’s the holy grail…no, better forget it, even though he’s cute as blue haired anime boy could possibly be.