Oh the humanity!
Down goes Frazier!
Havlicek stole the ball!
Cubs win the division!
You like me! You really, really like me!
Keep fuckin’ that chicken. (Probably not.)
I’ve picked up all these quotes through cultural osmosis. What are some others?
#Winning
But I suspect this one only has a few more weeks/months left on it.
Lighten up, Francis.
Maybe it is because I am not American, but I don’t recognise a single one of those.
Actually, I tell a lie. I recognise “Oh the Humanity”, but surely that was from a news broadcast and not from popular culture?
Who shot J.R.?
Today is a good / bad hair day.
Oh my stars!
Calliing Dr. Bombay! Calling Dr. Bombay!
Get…OUT!!
Oh. My. GOD!!!
De plane! De plane!
All you need is love.
I could spend all day doing this, but I’ll let someone else chime in.
Spam.
Heeeere’s Johnny
I did not know that!
I did not have sexual relations with that woman
Read my lips, no new taxes
It is better to look good than to feel good
Because shut up, that’s why-- O.K., this is only iconic in my house. Also, I strained not to have any Simpsons quotes.
Yeah they’re all US centric except for the 1st one.
1 Hindenburg disaster
2 Howard Cosell announcing Joe Frazier vs. George Foreman (1973, boxing)
3 Johnny Most announcing Boston Celtics vs Philadelphia 76ers (1965, basketball )
4 Harry Caray announcing Chicago Cubs (1989??)
5 Sally Field, Best Actress Speech 1984 Oscars which I just found out is a misquote. It’s actually “…I can’t deny the fact that you like me, right now, you like me!”
I’ve fallen and I can’t get up!
Where’s the beef?
[shrillBluecollarBritishwomanvoice] STOP SAYING “SPAM!!!”[/shrillvoice]
And now for something completely different…
BTW I was going more for real life instead of movie/tv quotes. Maybe I should not have used the phrase pop culture.
A few more
“Can we all just get along?” -Rodney King
“If the glove doesn’t fit, you must acquit!” -Johnny Cochran
“Segregation now! Segregation tomorrow! Segregation forever!” -George Wallace
I like it. What is that one from? 
More Cow Bell.
“…Penis!”
“DON’T SAY PENIS IN THIS HOUSE!”
“Aw, penis, penis, penis! Big fucking erect penis!”
“Heineken?! Fuck that shit! Pabst Blue Ribbon!”
Well, either that, or you could have put your OP somewhere other than Cafe Society. 
Okay, real life. Let’s see…
“I am not a crook.” Richard Nixon
“Don’t look back. Something might be gaining on you.” Satchel Paige
“It ain’t over 'till it’s over.” Yogi Berra
“We’re more popular than Jesus now.” John Lennon
How 'bout Damn the torpedos. Full speed ahead!
“We’re gonna need a bigger boat.” ~ “Jaws”
“Yet, Today I consider myself the luckiest man on the face of the Earth.” Lou Gehrig
How YOU doin’?
Good idea. Thanks.
Would a mod move this to the proper forum and change the title? Maybe something like “Iconic quotes that have crossed over into pop culture”