Bah. Hitman would just poison the power pellets.
Sure, Max Payne has got the bullet time going for him (I’ve only played the demo – does the real game explain why he’s got this ability?) but Denton has got cyberware. If he can’t pick you off with a sniper rifle, he can use the tranq dart and not even have to be around to watch you drop. Plus, Denton has the most hardboiled voice in modern gaming.
What? Solid Snake isn’t invited to this party?
Oh wait, maybe that’s him in the cardboard box in the corner…
It depends on which ending you choose, but in 2 out of 3 methods JC wins. He could be the physical manifestation of an omniscient and omnipresent force that controls the world in an iron grip. If that’s the case he’s impossible to kill, impossible stop, and can do whatever he wants.
Or he could be one of the higher ups in the Illuminati in which case he’s made arrangements to deal with his oponents before even showing up.
Of course, if you chose the third ending then he likely still wins because of the massive plot hole involving the plague that didn’t get resolved and never will be able to with the world’s infrastructure destroyed. As a result, it’s likely that the other three died a horrible lengthy death before encountering him and he wins by default. Since he dumped the supertanker full of the disease into the Hudson without any concerns about contamination those who live in New York (Max Payne, not sure on Rieper, Duke lives in LA) are almost certainly dead. But that’s not a sure thing…
I’m with the Master Chief on this one. He never misses. 
Yeah, but in the sequel, you can select 1st-person mode, so it’s in. 
In the game manual, it says something like, “Why can Max slow down time? We don’t know. Maybe he just goes into a state of extreme concentration. But it doesn’t matter.”
[spoilers for Deus Ex]
You know, JC is really screwed in the Helios and Illumanati endings, because he is famous and important, and killing famous and important people is what 47 does. Yes, he has become a godlike omnicent entity, but he still needs to sleep.
And remember about ballistic protection: The fiber wire penetrates the shield. And no fussing about strangulation not working on someone with backup lungs. Having the blood flow to and from your brain totally halted is better than a pack of trank darts.
So he kills him. And then JC is reassembled from base molecules on up if he had the Helios ending. In that ending he is God (hense the name JC; perhaps the least subtle game name since “Duke Nukem”). He can make life, he’s omniscient, he’s omnipresent, he doesn’t need to sleep and couldn’t if he wanted to since he’s wired into all the information in the world. His body might become inert but his mind is still everywhere, still active, still doing.
In the Illuminati ending he’s not really dead and it was just a complex plan of the Illuminati any way. Fnord.
Well, given the spoilers for DX2, JC Denton isn’t godlike, suggesting the Illuminati ending. And even so, 47 would ‘win’ the moment the kinetic energy-charged metal hit the skull. The fact that 47’s laptop would subsequently explode and kill him is irrelavent.
Heh. Deus ex: God from.
Of course, all this is assuming that Garett doesn’t just blackjack them all.