Well, who? I’m guessing that the two ex-cops would team up to take on the mass murderer/sex offender, only to walk into an ambush. Max would discover that no reflexes will save you from an explosive. JC will escape due to his augmentations. He will sense a warm body through a near wall, and send his spy drone to investigate. The possibility that the body could be a recently killed distraction will arrive in his brain at the same time as the ‘tzing’ of fiber wire.
Go Hitman Go!
The Marine from Doom would get hold of a BFG 9000 because he’s memorized all the secret item locations on the level, and then he’d blow 'em all away with one shot.
Gordon Freemen would sneak up and beat them all down with a crowbar. That man doesn’t make a sound.
The guy from Grand Theft Auto 3 would kick all their asses.
I’m with tracer , failing that - Max Payne due to his comments alone 
Bah. JC would pull out his energy deflection and agressive defence augmentations, and a fully modded sniper rifle. HEAD SHOT! Freeman would bonk Max on the head once and get shot due to bullet-time before he could draw back for his second swing.
And Mr. GTA3 gets into and out of cars all day long. That’s not healthy in a world with Mr. 47. He has car bombs. Lots of car bombs.
They’d obliterate each other in a testosterone critical-mass detonation.
The original 2-dimensional Duke Nukem would be the only survivor becuase he can turn sideways and become invisible.
LOL!
I take back what I said before about the Space Marine from Doom being the winner. He can’t climb over any obstacle that’s more than a foot tall. (But he does have the uncanny ability to fall from any height without getting hurt…)
Since Duke is a washed-up has-been who hasn’t had a hit in a long time, I have to believe that he would definitely lose.
My money’s on Max and Denton. Duke’s a weenie, and Rieper’s adept at stealthy wetwork, not full-scale battles.
'Course, the Master Chief would kick all their asses. 
I suspect Duke would survive, if not win, by default–he would insist on only showing up when he was good and ready, and provide only press materials about himself as they waited. The rest of the fellows would get bored and start the melee without him.
Max and JC would use multiple quicksaves and -loads at every corner, while 47 is more constrained regardless of how easy he’s taking it. That’ll give them the edge in a single straight-up fight, but pretty much even out in a more mixed challenge.
That’s the thing. When it comes to fighting, Max owns, due to bullet-time. The ability to shoot and dodge at 5 times normal speed is almost as good as a barrel of augs. But Tobias could take both of them, because he doesn’t fight fair.
Sargeant Eddings from Pathways into Darkness would put up a brave fight, but hindered by the fact that nearly all of his weapons that had been designed within the last 60 years would have been damaged just enough to be useless, he’d meet a sad end…only to be replaced by a similar-looking Space Marine who has memory problems, a knack for surviving falls, and a “7” fetish.
(The Tru7h is out there)
The only way Tobias could win is if Max and JC spent twenty minutes staring at a computer screen, or took a completely predictable path when walking through the city (ignoring the bald man dressed in a suit who, oddly enough, seemed to be following them).
Sorry, but Rieper hasn’t a chance.
My money is on Cate Archer. All of them would stop and admire her little kitties (II) and poodles (I) and BOOM. Anyone who survives will be taken in by the long legs and cleavage just long enough for a shot to the head.
I can’t believe that no one’s mentioned Lara.
That’s because Lara’s a two-bit hasbeen wannabe action game star. Third-Person Shooters need not apply.
47’s a third person shooter. But Lara’s two bits are all there ever was to her.
I’d have to go with Cate too. Doesn’t matter what the other people have, she’s got laughing gas and a tommy gun. Or, failing that, bananas! Augmented legs and bullet time wont do shite if you’re stuck on your arse!
Pacman would eat them.
Go, Pacman!