Which one would it be, and why?
Right now, Alabama is really an inviting target…
We could do away with Wyoming and turn the whole state into a National Park. That would be kind of fun. The same is true of Hawaii.
California, without a doubt (sorry Bone).
What happens to the people in it?
Can we coincide the zapping of Florida with one of those trips to Mar-a-lago?
They are also ranked as the most religious state, which is extremely incongruous given the other stats.
I think the South should secede again, and the North should let them.
The state of grace. Got no use for it!
Is it?
I’ll vote for Florida, but I’ll keep my reasons to myself.
What about the other 39,999,999 of us? 
Take Christians (I am most familiar with that religion), who were admonished to care for the sick and ill and poor, and yet believe that people who are relying on government help in those areas are lazy good-for-nothings. IOW, they behave in an un-Christian manner, as evidenced by their governmental policies. I find it hypocritical at best, hence my comment.
Since the OP doesn’t state that the state has to be obliterated, I vote that Rhode Island and the Providence Plantations be absorbed into Connecticut, to become Connecticut and Rhode Island and the Providence Plantations.
… and The Providence Plantations.
I’m kinda with Chefguy on this one. If the Southern states want to secede again, I think we should let them. Same thing for SoCal. You may leave, but don’t take anything north of the Monterey County line.
I believe that iamthewalrus(:3= was implying that hypocrisy on these subjects is a common-if-not-dominating attribute of american christians. If so, I agree with him. Holding to the values you describe as ‘christian’ would be difficult for anyone, and the fact that in America christianity is closely associated with social conservatism, which itself is closely associated with republicanism, which is closely associated with sodomizing the poor and the lower middle class with a rusty rake makes expecting christian politics from a christian an extremely optimistic position.
Yes, I was thinking that religiosity is correlated with poverty, so the most religious state being the poorest (and worse on other metrics that also correlate with poverty) wasn’t at all surprising to me. The opposite of incongruous.
I’d say Maryland. I just don’t like the shape of it. Too confusing.
Canada.
Hey!! It’s not our fault the Potomac has such a meandering path! 
No problem! Just take your western border-line with W. Va. and continue that line due south to the Virginia / North Carolina line and make that your new border.
You’ll chop off some of West Virginia, take the eastern two-thirds of Virginia (leaving it as a wee, mountainous rump with Roanoke the new capitol), and presto! Nice simple shape.
California.