Is anyone really seeking an artificial "genetically selective plague"?

I’m sick at home and watching In Search Of on the Sci-Fi Channel, and they ran a piece on Nikola Tesla’s legendary “death ray.” (Stop that snickering.) Out of curiosity I looked up “Death ray” on the Wikipedia (http://en.wikipedia.org/wiki/Death_ray) and came across this bit at the end:

:eek: :confused: :eek:

I don’t think well of PNAC but that seemed just too much to believe. There’s nothing about it on the Wiki article on PNAC. I looked on the PNAC website (http://www.newamericancentury.org/), but the site’s search engine doesn’t work. I googled on “genetically selective plague” and found a site on bioweapons with this comment – World Council of Churches

No hint anyone at PNAC or anywhere else has seriously advocated such a line of research. Have any of you heard of such a thing?

(Not a new idea, BTW. In Robert Heinlein’s 1949 novel Sixth Column, the U.S. is conquered and occupied by the “Pan-Asians”. A few Army scientists hiding out in a secret research facility discover a new kind of energy field which, among many other miraculous things, can be used to make a death ray that can be adjusted to kill only one particular species, and even one particular race within a species. You could fire it into a crowd and it would kill only the Asians, or only the whites, etc.)

What better weapon than a genetically targetted plague? Kill your enemy and leave their cities and infrastructure totally intact and you never have to fire a shot! Move in when they are all gone.

That such weapons has been investigated would hardly be surprising. What also would not be surprising would be to find absolutely no one admitting to looking into it. Short of a credible whistle blower I doubt that info would ever get out. Such a weapon would freak people more than someone having nukes (it would freak me out more anyway…a LOT more).

Pray such things are never developed.

Not since H. G. Wells and “War of the Worlds”. The aliens were killed by the common cold.

In a sense, the importation of diseases like smallpox to the New World by European explorers/traders had a similar effect. The lesson here is not so much that a plague has to be especially virulent, just that it has to be something your immune system has never seen before. So someone could engineer something like a flu mutation for which your immune system has no antibodies, and bingo! - a new pandemic.

Could it be genetically selective? Why not? There are already a lot of genetic diseases/disorders out there, ranging from nail-patella syndrome to Tay-Sachs and hemophilia.

There’s a difference, though, between disorders that are caused by gene defects or undesireable interactions between genes (generally the result of inbreeding in a small population, or disorders rare enough not to significantly affect reproductive fitness), and a genetic subceptibility to viruses or bacteria. Sure, various poxes and plagues killed off a majority of the New World Aborigonies, but it wasn’t because the Eurpeans were “naturally” more resistant to infection. The difference was that the Eurasians, who had been participating in animal husbandry for thousands of years (by which the diseases passed from domestic animals to humans) and had gone through a gradual sifting process by which weaker and less adapted infectious organisms had already killed the “weaker” members of the population. The ones that were left, and especially those hardy enough to survive a perilous ocean voyage and attendent hardships were far better able to resist infection.

By the time the Europeans landed in the Americas, human bacteria/virus genes had been engaged in a several millenia-long arms race of virulence and resistance; a race in which the Clovis people unintentionally opted out of by emigrating to the New World. Being less prepared to resist the now-well-adapted microbio invaders, infection raged like a California wildfire in October.

The differences in nuclear genes between different “races” are almost slight, not only because the short amount of time (tens of thousands) of years for genetic divergence, but also because of the interbreeding that occurs whenever human populations encounter each other. With the exception of extremely isolated populations that could more easily be destroyed by more conventional means, there just isn’t (generally speaking) enough difference to make a clear distinction between races. We may look a lot different, but so does a Great Dane from a Pomeranian, yet both are more alike than either is compared to a coyote.

On the other hand, if you could figure out a mechanism to link your hypothetical selective plague to a particular genotype, you might be able to target all (or most) people who exhibit a certain phenotype. For instance, you might be able to target all blue-eyed people (or at least those whose gene for blue eyes comes from the same population.) But most racial identification is due to phenotypical expressions (hair color and form, skin color, et cetera) that are the result of the confluence of a number of different genes.

One method that might work, again assuming some kind of discriminating mechanism which can target any particular gene sequence, is to use the mitochondrial DNA which are passed down directly from mother to child, and therefore are identical for all members of a lineage accounting after accounting for random mutation. This is one of the ways in which bioanthropologists track the divergence of human populations. (Given a constant mutation rate, you compare samples for differences and back-calculate the time needed for divergence.) You’d still pick up mulattos whose traits from the “undesired” population aren’t predominate or are dilluted (and there’s a lot more of them than you think, especially in the Americas) but you’d be limited to a single lineage.

I don’t know how you’d do this, though…or why. People seem to be pretty effective in acting on their cultural xenophobia with guns, machetes, gas chambers, napalm, and any other number of horrors without needing to bring in the eggheads.

I’d forgotten about “Sixth Column”. Heinlein seemed to have a burst of xenophobic output for a while (see “Farnham’s Freehold” for another example) before settling down to attempt at integrating every story he ever wrote into his increasingly tenuous “Future History”.

Stranger

I’m not an expert, but if I was the lead scientist in some evil genetic weapons team I wouldn’t want to unleash this anywhere. The differences between the ‘races’ is so slight that it seems the virus/bacteria could easily mutate and come back to bite us in the behind.

How about a sophisticated swarm of nanobot ‘gray goo’ that could indentify superficial characteristics instead? Or, if the target city/area is homogenous, a neutron bomb?

To be fair, the story idea for Sixth Column was developed and pushed on Heinlein by editor John W. Campbell, and Heinlein was later rather embarassed about it. (See http://en.wikipedia.org/wiki/Robert_Heinlein, http://en.wikipedia.org/wiki/Sixth_Column.) Furthermore, both Sixth Column and Farnham’s Freehold can be read as “the shoe is on the other foot” stories, written to illustrate that what people are not necessarily “natural masters,” as was widely supposed at the time, and that a society where whites are enslaved by other races is at least conceivable.

I hope that occurs to those megalomaniacs at PNAC – assuming the Wikipedia is right that they’ve seriously suggested developing such weapons.

Sorry, I meant, “written to illustrate that white” people are not necessarily “natural masters,” as was widely supposed at the time." (“Widely supposed” by white people, that is.)

That’s what I was thinking of, although I probably didn’t express it very well (or completely). If you could tie some disease like a mutated smallpox or cholera to something like the gene that transmits something like Tay-Sachs, then you would have a disease that would affect only Tay-Sachs victims/carriers. Probably overkill, since Tay-Sachs is untreatable and fatal, but it illustrates the principle I had in mind.