Muscular Hypertrophy
It is well known that RT [resistance training] induces muscular hypertrophy through mechanical, metabolic, and hormonal processes. The process of hypertrophy involves a proportionate increase in the net accretion of the contractile proteins actin and myosin as well as other structural proteins. Mechanical loading leads to a series of intracellular events that ultimately regulates gene expression and protein synthesis. RT may alter the activity of nearly 70 genes, up-regulate factors involved with myogenesis (e.g., myogenin, MyoD), and down-regulate inhibitory growth factors (e.g., myostatin). Protein synthesis in human skeletal muscle increases after only one bout of vigorous RT and peaks approximately 24 h postexercise. This anabolic environment remains elevated from 2 to 3 h postexercise up through 36-48 h postexercise. Other factors such as fiber type, muscle action, metabolite formation, amino acid intake, and endocrine responses (testosterone, growth hormone [GH], cortisol, insulin, and insulin-like growth factor I) contribute to the magnitude of hypertrophy. Optimal hypertrophy may comprise maximizing the combination of mechanical (use of heavy weights, ECC actions, and low to moderate volume) and metabolic (accumulation of metabolic waste products) stimuli.
The time course of hypertrophy has been examined in previously untrained individuals. Neural adaptations predominate during the early stages of training. Muscle hypertrophy becomes evident within the first 6 wk, although changes in the quality of proteins and protein synthesis rates take place much earlier. From this point onward, there appears to be interplay between neural adaptations and hypertrophy in the expression of strength. Less muscle mass is recruited during training with a given workload once adaptation has taken place. These findings indicate that progressive overloading is necessary for maximal muscle fiber recruitment and, consequently, muscle fiber hypertrophy. This also indicates that alterations in program design targeting both neural and hypertrophic factors may be most beneficial for maximizing strength and hypertrophy.
PROGRAM DESIGN RECOMMENDATIONS FOR INCREASING MUSCLE HYPERTROPHY
Muscle Action
Evidence statement and recommendation:
Evidence category A. Similar to strength training, it is recommended that CON, ECC, and ISOM muscle actions be included for novice, intermediate, and advanced RT.
Loading and Volume
A variety of styles of training have been shown to increase hypertrophy in men and women. In untrained individuals, similar increases in lean body mass have been shown between single- and multiple-set training, although there is evidence supporting greater hypertrophy enhancement with multiple-set training. Many of these studies in previously untrained individuals have demonstrated that general, nonspecific program design is effective for increasing hypertrophy in novice to intermediate individuals. Manipulation of acute program variables to optimize both the mechanical and the metabolic factors (using several loading/volume schemes) appears to be the most effective way to optimize hypertrophy during advanced stages of training. RT programs targeting muscle hypertrophy have used moderate to very high loading, relatively high volume, and short rest intervals. These programs have been shown to induce a greater acute elevation in testosterone and GH than high-load, low-volume programs with long (3 min) rest periods. Total work, in combination with mechanical loading, has been implicated for both gains in strength and hypertrophy. This finding has been supported, in part, by greater hypertrophy associated with high-volume, multiple-set programs compared with low-volume, single-set programs in resistance-trained individuals. Traditional RT (high load, low repetition, and long rest periods) has produced significant hypertrophy; however, it has been suggested that the total work involved with traditional RT alone may not maximize hypertrophy. Goto et al. showed that the addition of one set per exercise (to a conventional RT workout) consisting of light loading for 25-35 repetitions led to increased muscle CSA whereas conventional strength training alone (e.g., multiple sets of 3-5 RM) did not increase muscle CSA. The addition of the high-volume sets led to greater acute elevations in GH. However, light loading alone may not be sufficient as Campos et al. have reported that 8 wk of training with two sets of 25-28 RM did not result in Type I or Type II muscle fiber hypertrophy. Thus, it appears that the combination of strength training (emphasizing mechanical loading) and hypertrophy training, that is, moderate loading, high repetitions, short rest intervals, which emphasizes total work (and reliance upon glycolysis and metabolic factors), is most effective for advanced hypertrophy training.
Evidence statement and recommendation.
**Evidence category A. **For novice and intermediate individuals, it is recommended that moderate loading be used (70-85% of 1 RM) for 8-12 repetitions per set for one to three sets per exercise.
**Evidence category C. **For advanced training, it is recommended that a loading range of 70-100% of 1 RM be used for 1-12 repetitions per set for three to six sets per exercise in periodized manner such that the majority of training is devoted to 6-12 RM and less training devoted to 1-6 RM loading.