If you look here, you’ll see the VERY first journal paper with my name on it 
WHOOOOOOT!
I’ve gotten published!
In the Journal of Virology too! One of the best journals for the field of Virology!
HOT DAMN!
Congratulations. Do you mind if I wait for the movie to come out though?
Woo-hoo—congrats!
Awesome! Congratulations, CRorex! And a very nice item to mention on a resume, should the situation arise.
Best,
karol
Congrats! Is this going to help us cure AIDS?
It’s rather simple.
The method of primary infection for HIV (and SIV) is through mucosal tissues. (during sex) The concept is that Dendritic Cells, which play a role in activating the immunesystem encounter the virus and then present it to T-cells. This is normal in most infections, after presentation the T-cells begin to attack the pathogen. Unfortunatly HIV and SIV infect T-cells, so the DCs are infact HELPING the course of the disease.
Generally it’s believed a molecule called DC-SIGN (Dendritic Cell- something or other) plays a role in tranfering the virus. So, the lab I work in generated antibodies against DC-SIGN. Then we started assaying the antibody for activity against DC-SIGN. We found that the antibody did bind to DC-SIGN.
We then looked at the effects of DC-SIGN on viral replication. Transformed cells expressing DC-SIGN showed a 10+ times increase in viral replication.
Next we looked at how the antibody and DC-SIGN would act in a simulated infection. To do this we isolated white blood cells (PBMCs) from whole blood of big tailed macaques and seperated the cells into CD14+ (dendritic and macrhopage precursors) and PBLs (mainly B and T cells). After stimulating both populations into differenciating we’d pretreat the DCs with the antibodies then expose them to virus. Then we’d combine both DC’s and the PBLs into the same culture and assay the viral replication.
We have one antibody that knocks out 75+% of viral replication!
Like most of aids research, this paper is more explaining part of the viral life cycle. Once we fully know the life cycle of this virus we can start developing more drugs and compounds to disable ALL stages of viral replication.
Now I just have to finish the data for the new drug I’m screening
Hrrm after rereading the paper, I’m struck by how bloody confusing it is unless you’ve been working on it. I mean nothing that we did was particularly difficult, but with all of the jargon in the paper it makes it seem what we did was totally alien.
Wow, congratulations, CRorex!!
Also - your research looks very promising, I can see why the Journal was interested. Best of luck for future success!
Congrats!!!
You lost me right after that part, but congratulations just the same!
My warmest congradulations! Truly “Fighting Ignorance”.
Yay!
Congratulations, CRorex! A great achievement!
That’s wonderful! And 4th author isn’t that bad of a spot, considering how many names are on that paper. Congrats!
Congratulations!
Heh, wait til you’ve worked on a paper, stepped away for a while, and then come back to finish it. Very “I did that??”
Congratulations on your publication, CRorex. Journal of Virology, I’m impressed!
Congratulations. Now you won’t perish.
Yeah, really. What Bosda Di’Chi of Tricor said. I say I ‘fight ignorance,’ and all I do is sit on my butt. You’re out there on the front lines, CRorex. Congrats.
Thanks everyone
As for the ‘fight ignorance’ comment: It’s making me blush!
(You should see us working on the NY Times Crossword during lunch 
5 people with 9 biology degrees between us and we can’t figure out a 8 word for “Where DNA comes from”)
Congratulations! what a fun event. Enjoy, enjoy.