The director of the department (yes, director - for an entry level monkey-can-do-it lab job) asked me the following question during a job interview. Note, I had worked there before as a student and knew the job fairly well, this was for a full-time position after graduation (condensed for typing ease!):
D (director) - Say you’re working on something, and your manager tells you they need it tomorrow because the client will be here, but your trial results (he gave a specific scenario) just don’t make any sense, what do you do?
Me - I’d double check my work, make sure all my settings were correct, that I hadn’t made a mistake in the sample preparation, etc. i’d reread the method to see if there was a note or comment that I hadn’t noticed which might explain the error.
D - well, if you don’t find a mistake and the equipment is working and the method is exactly what you did, then what?
M - I’d ask around, coworkers, supervisor, manager, etc, to see if anyone else had encountered this particular problem and how they solved it.
D- there’s no one around. It’s 6pm and everyone’s gone home.
M - (joke that Joan never goes home that early then go on to say) i’d look in previous notebooks, other available data to see how other people did the work, to compare
D - you’re the first to ever do this work. The manager is really counting on you to get this done.
M - well, I’d try and contact the manager, perhaps they felt it was important enough to leave me their home number…
D - you call, they aren’t home. there’s no one at all to help you, anywhere on the planet.
M - sooner or later, I’d have to simply accept that I can’t resolve this problem, and I’d go home and do my best to resolve it in the morning. I’m sure the client would accept a day’s delay in exchange for me making sure the results were true and reliable.
He was finally satisfied with that. The way the guy went on and on (trust me, this was the short version!) I was beginning to wonder if he’d have the lab blow up, the planet invaded by aliens and the universe collapse on itself if I continued to try and troubleshoot the problem. I wonder how soon I could have said “I’d give up” and still get the job?
This guy also asked me if I thought the (c)GMP guidelines and ICH and FDA regulations are stupid and they just result in us wasting our time trying to meet their criteria. We are a contract manufacturing and development pharmaceutical company. I don’t think too highly of this director!
Sorry for the hijack, but I just had to comment on this “hypothetical!”