I’m using a Dell that’s a few years old, and running Windows 8. The new kitten walked across the touchpad/keyboard, and now the touchpad buttons aren’t working. The laptop was working fine before then. I’ve tried variations of Alt+F5, the touchpad button in the row of F keys, shift+F keys as suggested by a Google search. I can use the touchpad to move the mouse, but neither button works.
I tried to change the mouse settings to switch left/right mouse buttons (in an attempt to click+apply to reset and change them back), but that hasn’t helped, either.
Most Laptop touchpads have a somewhat hidden button in the corner on the main pad itself, top left or top right if not try the bottom corners. When pushed you will feel a click. It has the function of toggling the on and off of the touchpad.
Have you checked the mouse driver settings? It should be under Control Panel -> Mouse. Or you can probably get to it by opening the Start menu and typing “mouse”. There is usually a separate tab for the touchpad settings.