Last letter = First Letter, min 3 syllable word chain

Ratatouille

ectomorph

holographic

correspondence

equatorial

loxophthalmus

superannuated

deportment

tertiary

yogibogeybox

xanthophyll

labyrinth

hypertrichologist

Trinidad

And the big Mississippi
And the town Honolulu
And the lake Titicaca
The Popocatepetl is not in Canada
Rather in Mexico, Mexico, Mexico…

Er, sorry. Got carried away there.

differentiation

Neosporin

neoclassicism

Mercurochrome

eleemosynary

yarnwindle