It just kinda depends on how much you care about conflicts of interest.
Chrome does have uBlock Origin Lite now, which is generally good enough, but not quite as powerful as the full version (which is only on Firefox now). Google is ultimately an advertising company, after all, and they’re not going to go out of their way to ensure compatibility for ad-blocking plugins, and they’re going to keep trying to squeeze ads in in various ways (See Manifestv3 controversy and FLoC)
Brave is basically a reskinned Chrome with adblock and some other stuff built in, but it’s also a commercial endeavor and has some crypto-advertising crap. On one hand it was made by Brendan Eich, who invented Javascript (the underpinnings of the whole interwebs) and was the former CEO of Firefox/Mozilla. On the other hand he was kicked out of Mozilla for being anti-gay, and is a regular Republican donor. So some of that Brave money will flow directly to those causes. (But I’m sure the same is true of Chrome and Safari and any other browser; those companies are all kowtowing to MAGA now.)
Most browsers are reskinned Chrome: Edge, Brave, Opera, Samsung Internet, etc., so ultimately they’re all subject to Google’s whims. The only ones that aren’t are Safari and Firefox, and the upcoming Ladybird and Orion. Most of them nonetheless have “good enough” ad blocking.
The only truly open one is Firefox (hence why it has the strongest ad blocking), but Firefox is also over 80% funded by Google as a weird anti-anti-trust thing, so they’re ultimately still tied to Alphabet’s whims. (edit: correction, only 83% of Mozilla’s revenue comes from Google, not 90%+)
Google pretty much owns the entire web and it’s really only by their grace (or insufficient fucks given) that we have adblockers at all…
If you don’t care about any of that, use whichever browser or ad blocker is good enough. Most of them are. Firefox and uBlock Origin are the main actually open and non-commercial ones.
FWIW I used and loved Chrome for 20+ years, and only switched back to Firefox last year (grudgingly) after the Manifest v3 change that killed UBO on Chrome. Firefox is slow and buggy and I generally dislike it, but it’s still worth it to me… that’s just how much I hate ads.