Most gruesome murder in a horror movie?

Cafe Society
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The Japanese Guinea Pig series of movies, particularly the first two, are exceptionally gruesome. The first one, Flower of Flesh and Blood, only has one death scene, but it’s 90% of the entire movie. A woman is kidnapped, given a drug to paralyze her and slow her heartbeat, and then methodically snipped, sawed and hacked into pieces for the next 45 minutes. It’s so realistically done that for a while it was believed to be an actual snuff film.

The later videos in the series are played more for laughs. The second film The Man Who Couldn’t Die, now that I think about it, shouldn’t even count, since nobody dies. A dejected loser decides to end it all, only to find that he just can’t die. He then spends the rest of the film ripping himself to shreds.

Also, the wheel of skin from Jisatsu Saakuru (Suicide Circle) was more disturbing than many film deaths I’ve seen.

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Griffin Dunne getting chewed up by the werewolf in An American Werewolf in London was pretty unnerving.

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My grossest would be in some movie called The Surgeon, where a guy has his lips stitched together, and then a pump is stuck on him that pumps the blood out of his body and into a jug.

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The first death in Cube.

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One that always stuck with me, from a film that I never caught the name of.

Young chap has chains tied to his wrists and ankles. The other end of both chains is tied to the back of a truck. There is a tree inbetween him and the truck. The driver floors it, the chains go taught, the victim’s spine is crushed against the tree until his arms and legs are ripped off.