Your first bike should be something that is moderately powered and easy to handle, this would exclude things like big touring bikes and crotch rockets. There are lots of machines out there that offer good power and great handling characteristics that don’t weigh half a ton and being able to go from 0-60 in 3 seconds isn’t for the faint of heart.
My friend is a riding instructor and he got to drive a number of new bikes that were provided by dealerships for the training courses. His normal ride was an 1100cc Goldwing but one day he was driving a 600 Ninja while he taught highway skills. He pulled out to pass a truck and thinking he was driving his Goldwing, dropped the bike down a gear and punched it. The students were really impressed at the instructor pulling a quick wheelie at 50mph and then going by the truck at 90mph.
Become intimate with how your bike feels and performs, if anything seems amiss have your bike checked immediately.
Maintainence is extremely important as having a mechanical failure on your bike can be much more dangerous than having a similar failure in your car. Make sure everything is working to spec before you head out.
Wear proper clothing, this is what will keep your skin intact if you have to lay your bike down. I agree with others that the guys I see riding in tank tops, shorts, and sneakers are guys who have never laid their bike down. Even in hot weather you’d never find me riding without my leather jacket, jeans, steel toed boots, and gloves.
Your helmet needs to be fitted properly, once your helmet is on it should not be able to slip or move from it’s proper position.
I would also suggest wearing a full face helmet with a face shield as bugs, rocks, and things like suicidal birds can cause a great deal of damage.
I used to ride an old Honda 750 Supersport with some serious racing modifications. It wouldn’t compete with any of today’s ultra light crotch rockets but it was a great machine to tour on and could cruise at high speed all day without complaint. It was equipped with a 3/4 sport fairing and a decent windshield that made long trips really comfortable and much safer.
So I’m doing about 70mph and since the road is clear I straighten up a little and open my visor a few inches to allow some air to circulate, this raised my head just above the level of the windshield. At this very moment a wasp comes over the top of the windshield which was level with my bottom jaw, it skipped off the bottom of my visor, and hits me right below my eye. The impact was still hard enough that I had to pull over and wait for my eyes to stop watering but had I not been wearing a full face helmet the big would have hit me dead on at 70 mph. I still loked like someone had hit me with a bat.
A friend of mine used to mock me for my safety issues, that was until he ate a bee while doing 70 mph.
Finally, treat everyone else on the road like they are out to get you.
They are. 