But Horatio is a pretty big character.
The 1998 Canadian film Last Night. Everyone knows the world is going to end at a specific time, and has known for weeks or months. The movie shows the last few hours of several characters in Toronto. IIRC there us no explanation of either why the world is ending or how everyone knows it. And then everyone… dies.
Very good film, I thought.
That’s not the only thing it was “also called.”
And Then There Were None shows the first edition’s cover, with its original title.
:eek:
Speaking of old sitcoms, there was also Sledge Hammer, except
ABC decided to renew it, so they had to make Season 2 a prequel.
And that’s a proper use of the spoiler box! 
Implied…or implode?
He fell into the fucking sun!
The Departed - Yeah pretty much everyone.
2001: A Space Odyssey - Well technically David Bowman doesn’t die. But something happens.
Quarantine
panamajack - No, that is not correct. We know that Matt Damon and others have an immunity.
Doctor Who.
The Doctor, of course, has died many times, and being a time-traveller, it’s pretty much guaranteed that anyone he interacts with is dead during some of his other adventures.
More seriously, The Church mostly qualifies
Except for the one girl that does escape, but then you see her unleashing the evil from the ruins, which is pretty much just as bad
You probably slept though it:
Melancholia.
It was self spoilered so you could just go home without having to watch the entire thing.
If TV shows count, well… forget the spoiler box. Howard Stern killed off the entire cast in the final episode of his sitcom Son of the Beach.
Just watched it. I want my 2 hours back. Yuck.
Monty Python’s The Meaning of Life possibly counts, though the characters persist in an afterlife. I’m guessing “afterlife” films don’t really count. Or films where the main characters are [un]dead, like Ahh! Zombies!, in which they become zombies at the start.
And there’s the film semi-referenced by The Meaning of Life’s section on death,
The Seventh Seal
A few characters are alive at the end, though I suppose it is implied they will die. Someday.
It seems that most of the non-horror ones that fit the OP are those in which all humans die. I’m surprised there aren’t more in the Hamlet mold, a tragedy in which just the major characters die. Which makes me think of one that fits, Akira Kurosawa’s Shakespeare-inspired
Ran. I just watched this and don’t recall if Kyoami (the “Fool”) was explicitly shown dead, but he’s not really a major character in the tragedy.
In the late 19th century and start of the 20th, both theatrical and novellated dramas were getting gorier and gorier, dreadier and dreadier, with people jumping off cliffs and poisoning themselves and heroines dying of consumption and… the line which came to be used to describe these is ¡se muere hasta el apuntador! (even the prompter dies!). Pedro Muñoz Seca’s La Venganza de Don Mendo (Don Mendo’s Revenge) opened in 1918 and has become one of the most-represented works in Spanish theater; it’s a very common choice for amateur groups.
There is a Venganza de Don Mendo movie, with Fernando Fernán Gómez playing Don Mendo, which some people have criticized because “it doesn’t even try to look like a movie, it’s just a theater recording with no public and retakes”. Well, yeah… but if it was a movie they wouldn’t be able to kill the prompter! Which, yes, Don Mendo’s Revenge is, AFAIK, the only play which truly does.
But not Infernal Affairs, which is one of the reasons it’s a hell of a lot better.
I take it you didn’t see the finale, or have edited out of your memory. Probably for the best.
I might mention something mentioned before, since I don’t want to go through an unspoiler something i might want to watch.
They’re not all dead yet, but will be shortly after the end of the 1982 science fiction film
The Thing
And the same for last year’s prequel of the same name
The Thing
Speaking of science fiction in nthat venue, everyone ends up dead at the end of the TV movie
also set in the Arctic/Antarctic “A Cold Night’s Death”
Everybody isn’t dead, but will bne doomed, at the end of the Original Series episode of
The Outer Limits’ “Feasibility Study”
Just as in the original story, everyone dies at the end of
the Roger Corman Poe films The Masque of the Red Death and (well, almost everyone) in The Fall of the House of Usher
The UK TV series
Dead Set - A terrific satirical horror about a global zombie outbreak which consumes the whole of humanity…except for the contestants for that year’s Big Brother. Needless to say, the fortifications of the BB house don’t hold out indefinitely, and all the characters either kill eachother or turn into zombies.
It’s a good thing they were Brits, I’m reasonably sure that Spanish BB contestants have to prove they’re braindead during the casting process.
The UK SF TV series, Blake’s 7. I don’t have to spoiler it, since it’s notorious for ending that way.
I fast-forwarded to see Kirsten Dunst naked. 
I forgot how to do the “spoiler” function 