Set in CA, but it was the old Orlando City Hall that was blown up in the beginning of the movie. (Roommate travelled into town and said it was fun to watch.) Replaced by an ugly building with an even uglier sculpture of a glass asparagus in the courtyard.
Ummm, no. That would be Houston, not Seattle.
Others set in Texas, just to name a few:
Places in the Heart
Giant
The Alamo
Terms of Endearment
Dazed and Confused
Bonnie and Clyde
JFK
Lone Star
True Stories
More films set (at least in part) in Georgia:
[ul][li]Gone With the Wind (of course)[/li][li]Forrest Gump - The park bench is in Savannah.[/li][li]Tobacco Road[/li][li]Scream 2[/li]Driving Miss Daisy[/ul]
A couple of my friends grew up in Cumberland. They think that the High School in the movie is one in Pawtucket.
Some more cool Baltimore flicks: Twelve Monkeys & Silence of the Lambs.
Alabama
[ul]
[li]“The Grass Harp”[/li][li]“To Kill a Mockingbird”[/li][li]“The Long Walk Home”[/li][li]“Forrest Gump”[/li][li]“My Cousin Vinny” (the case they try before the Honorable Fred Gwyn was in Alabama.) :)[/li][li]“Fried Green Tomatoes”[/li][li]“Crazy in Alabama”[/li][li]“Con Air” (the prison to which the convicts were being transferred was in Alabama)[/li][li]“Sweet Home Alabama” (in production)[/li][li]“4 Little Girls”[/li][li]“Wallace”[/li][li]“Eyes on the Prize”[/li][li]“Alabama: 2000 Light Years”[/li][li]Another Part of the Forest[/li][li]"The Bear[/li][li]“Blue Sky”[/li][li]“The Fighting Kentuckian”[/li][li]“Guess Who’s Coming to Dinner”[/li][li]“Judge Horton and the Scottsboro Boys”[/li][li]“Maximum Carnage”[/li][li]“Maya Lin: A Strong Clear Vision”[/li][li]“Miss Evers’ Boys”[/li][li]“Norma Rae”[/li][li]“Nothing But a Man”[/li][li]"The Phenix City Story[/li][li]“Polly: Comin’ Home!”[/li][li]“Selma, Lord, Selma”[/li][li]“Separated by Murder”[/li][li]“Swing!”[/li][li]“The Symbol of the Unconquered”[/li][li]“Wild River”[/li][/ul]
The above list is mostly from my own little cranium, but IMDB helped a bit.
The thing that always gets me about movies set in the South is that they seem, almost without exception, to have a powerful sense of place. People set movies in the South for the sole purpose of having that certain feel. I don’t think I’ve ever seen a movie set in the South just to have a generic place.
I think it was somewhere in Florida or California… the high schools in our humble little state aren’t that nice, unfortunately!
Indiana:
Hoosiers
Breaking Away
Knute Rockne: All American
Rudy
and I believe, A League of Their Own
Hey, Illinois, you forgot Vacation (unless I missed it) which I will now include in my list.
Vacation (that was lovely image of St. Louis they gave)
Tom Sawyer (all of the movies)
Smokey and the Bandit (passing through again)
The Day After
I’m sure there are some more really obvious ones but that’s what I can think of right now. Maybe some Jesse James movies or something like that.
More from Minnesota
A Simple Plan
Untamed Heart
Twenty Bucks
Also, I believe the working title of “Fargo” was actually “Brainerd”, but they realized no one knew where Brainerd was.
and isn’t Reality Bites set and filmed in Austin TX, NOT Houston?
How about Utah?
SLC Punk
Ruben and Ed
Plan 10 from Outer Space
By the way, a lot of the John Hughes movies were from Illinois. that includes Sixteen Candles, Breakfast Club, Weird Science. Of course we discover in Kevin Smith’s “Dogma” which starts in IL, that there is no town called Shermer in Illinois.
Again, ummm, no. Filmed in various Houston neighborhoods and landmarks - Montrose, House of Pies, Enron Building, etc. I lived there at the time it was being filmed, so I’m pretty certain it was Houston. 
Here’s the cite from the IMDB.
Meet Me In St. Louis
The Shepherd of the Hills
Kansas City
The Great St. Louis Bank Robbery
The rockumentory Hail! Hail! Rock n Roll
The made for TV movie Asteroid
I can’t think of too many set in Missouri or St Louis.
In Planes, Trains, and Automobiles there’s a couple scenes that take place and were filmed here in St Louis. (When Steve Martin cusses out the rental car lady)
National Lampoon’s Vacation has a scene when the Grizwolds stop and ask for directions that takes plce in St Louis. (While stopped, their hubcaps are stolen, and the car gets spray painted)
Anything filmed about Jesse and Frank James.
Huck Finn and Tom Sawyer films.
Of course, there’s Meet Me in St Louis, but that’s a Judy Garland musical, so we try to keep it quiet.
Escape From New York was filmed in St Louis cuz downtown was such a pit at the time. It’s been cleaned up since then.
I, too, am going to skip Los Angeles, except to list the ones I’ve actually witnessed being made:
Another 48 Hours
Guilt By Association
National Lampoon’s Loaded Weapon
Life Stinks
Escape From L.A.
Filmed in Waxahachie, twenty-plus miles south of Dallas, and twenty miles east of where my mother lives today. Trip to Bountiful and Tender Mercies were filmed here, as well.
Visited the set with my Daddy on our motorcycles back in '78.
Witnessed the filming, only nine years old at the time.
Other movies filmed (totally or partially) in or near Dallas that I have seen:
Logan’s Run
Armageddon
Bull Durham The interview at the end of the flick was filmed at Arlington Stadium; the rest was filmed in North Carolina.
State Fair Musical starring Pat Boone
The Apostle
Talk Radio
Batman & Robin According to IMDB. But I have no idea which parts.
Born on the Fourth of July
Robocop Dallas stands in for Detroit
Semi-Tough
Benji
Necessary Roughness
Problem Child
Strategic Air Command (1955)
The Big Show(1936) starring Gene Autry with a cameo singing appearance by Roy Rogers, as a memeber of the Sons of the Pioneers, before he was famous. Filmed at the Texas Centennial.
Ok, after a night of random thinking…
As someone else mentioned, Last of the Mohicans was set up near Lake George but filmed in NC. However, one scene in the movie was filmed on location. I forget which one it is, but when I went to camp back in middle school my counselor took us on a hike up to the top of a mountain to look off it, it was the very mountain they did a location shot from for the movie.
The non-trip parts of Road Trip are set at Ithaca College.