A very good friend of mine did exactly what you are contemplating several years ago.
Backstory: said friend–we’ll call her “Jane”–and her husband moved East from SCal so her husband could get his PhD from a big name school. After he got the degree, he became a professor there.
Fast forward twent-some years. Her husband became extremely disabled, and because he didn’t have tenure, he was discharged. Jane had been a stay at home housewife (no kids) and she re-entered the work force with a retail job.
They were hideously behind with their bills. Her husband had chronic, severe pain, brittle Diabetes, and other disabilities. Jane went to work at her retail job one day. She arrived to a big meeting, where Management told everyone the store was closing, and nobody had a job any more.
She drove home to find the County Coroner parked on her front lawn. Her husband had saved up his pain pills, and took his own life.
She got in touch with me in AZ, barely coherent. I told her she was coming to live with me. I said if everything there was simply too much of a mess for her to handle, she was to just walk out the front door, get to the airport, and I’d have a plane ticket waiting for her.
She put on her Big Girl Shoes and liquidated everything she had, except for the few items she could cram in her car. She brought her sewing machines, sewing projects, shoes, clothes, some books, her professional model Kitchen Aid mixer, and other miscellany. I plotted out a route for her to drive, made all motel reservations for her, and she arrived safely in AZ.
Purple, sometimes Life dumps on you. And it can be easier to just leave the mess than trying to clean it all up into something you can live with. I’m sorry you don’t have a VOW at your destination to give you a hand.
Decide where you want to go. Do a list of pros and cons, and also let your heart weigh in.
Decide when you want to go. Don’t go in winter. Just. Don’t.
Liquidate EVERYTHING. You will have enough to occupy your mind with navigating freeways and ramps and big trucks without trying to handle a U-Haul trailer. Take your clothes, some kitchen stuff, electronics, and ABSOLUTELY your favorite pillow.
Plan your route carefully. Decide how many miles (or how many hours) you want to drive per day. Make reservations at motels adjacent to the freeway (trust me on that one).
Have somewhere to stay at your destination.
All of this will take a LOT of research. Talk to people. Take suggestions.
Good luck on your adventure!
~VOW