Reading biochem the other day, I noticed it talked about DNA lesions/mutations but didn’t mention those in RNA. What, do they just not occur in RNA? Or are they less of a problem, for some reason that I’m stupidly overlooking?
And a specific question: OK, so cytosine deaminates to uracil in DNA, but it usually gets fixed. My book says this deamination is probably the reason DNA uses thymine instead of uracil, because if Cs deaminated to Us all the time and DNA repair enzymes didn’t recognize them as foreign, we’d have a lot more mutations, and our genome would be much less stable. But there are cytosines in RNA, right, so how come deamination in those cytosines doesn’t royally screw up our transcripts?
These might be dumb questions…it’s been a while since I’ve cracked the ol’ genetics book.