“Will your blood boil if you’re thrown out of a spaceship without a spacesuit? Reporting from the International Space Station: Scottie, Tori, and an unnamed prisoner scheduled to be executed within the week.”
“Is nicotine really more addictive than heroin? Tonight, using Mrs. Carpenter’s fourth grade class, we find out!”
“Can you really raise psychopaths by subjecting babies to sensory/emotional deprivation? In this, the first in a long-term series…”
“Once you go black, can you go back?”
Was the internet really designed to survive a nuclear war?
'This week on Mythbusters we’re going to tackle the biggest myth of them all. The Holocaust!"
“Is Kari Byron a real redhead?”
That would be very awesome. 
I seem to recall reading somewhere that the scene in the book and movie 2001 where Dave Bowman gets back on board Discovery after HAL refuses to open the pod bay door, spending a few seconds in hard vacuum without a spacesuit as he manually opens the airlock from the outside of the ship, was scientifically plausible, as much of Clarke’s fiction tends to be.
“Are there really three common words in the English language that end in -gry?”
Clark used the idea in several of his short stories. His reasoning is that, while the blood would boil if you had a cut, it was in a closed system and would take time to reach a vacuum. When he wrote about it, he included taking a deep breath to keep pressure in the lungs, the most likely place for something to rupture.
Back to the OP: “Does a head retain consciousness after being guillotined?”
“Tonight on Mythbusters, we’re going to skip the cornball jokes and obnoxious MTV/ADD jump-cutty editing bullshit.”
Bravo!
“Could controlled demolitions have really taken down the WTC? What would a missile do to the pentagon?”
(Actually, I’m half-serious. It would be hilarious to see them try to wire two gigantic buildings with all the needed explosives in that time allowed, then wait for an airplane to hit).
“Green M&Ms: Are the rumors true?”
Mythbusters tests the Mile High Club myth: Is it actually possible to have sex in an airplane bathroom?
Does Adam Savage actually keep those molds of all of the crewmembers in his home for his own sick pleasure? Find out when we kick down the door!
Who IS Cecil Adams? 
We really need to spread some urban legends along these lines. We could also say that she has peculiar tattoos on her breasts, and a very interesting birthmark on her buttocks.
“What really happened to Scottie Chapman?”
As Reality Chucjk points out above (and I have pointed out often on these Boards), Clarke did use the idea in several stories (The Other Side of the Sky, Earthlight, and The Fountains of Paradise – where it’s at least discussed ) besides 2001, book and film. He even prepared a statement defending the scene in 2001, and said that there were NASA studies to back up his claims.
This didn’t stop others from having people boil or blow up in low pressure – the films License to Kill and Outland, and Pierre Boulle’s novel Garden on the Moon, and Martin Caidin’s novel Four Came Back. Caidin (who wrote the books that became Marooned and The Six Million Dollar Man) was a test pilot at one time, and shoulda known better.
Is the brain of a super-smart person different from the rest of us? To find out, Adam and Jamie surgically remove the brain of Marilyn Vos Savant and examine it.
Do Altoids really make for sensational blow jobs?
Actually why couldn’t they do that experiment with a pig carcass and a vacuum pump? It’s not any logistically crazier than eating pop-rocks and soda until you explode, pissing on the third rail or shooting out the windows of jet plane.