What is “the straight dope” on what difference there is between the two, if any? I’m clueless as I can’t imagine, say tiny particles of broccoli, fitting into those little pills. So what’s “natural” about “natural vitamins”?
Natural vitamins are those derived from a natural source, like a plant, but synthetic ones are made in a laboratory test tube. The pure molecule is basically the same, but there could be differences.
If I understand this link correctly, synthetic vitamins are more likely to be racemic mixtures rather than a pure isomer of the molecule. That means that at one location in the molecule, the natural vitamin will always be oriented the same way, while half of the the synthetic molecules might be oriented the other way (think of your two hands - basically the same, but with a different orientation). Your body might need just the right hand one and not use the left hand one at all, but in the lab its hard to make one without the other, so you get some left with the right and your body just gets rid of the extra.
http://www.nutritionfocus.com/nutrition_supplementation/vitamins/vitamin_e_retained.htm