Nope, sorry.
Thora Birch, Benjamin Bratt, and Harrison Ford in Clear and Present Danger
with Willem Dafoe
You’re sure it’s not Susan Kellerman, right?
I’d have guessed James Earl Jones.
Ursula Andress, Burgess Meredith, and Maggie Smith were all in Clash of the Titans with Laurence Olivier
Barbara Hershey, Bruno Kirby, JT Walsh in Tin Men with Danny DeVito
Ok, let me catch up here.
Welfie correct on Clear & Present Danger, but it’s not Dafoe you’re looking for. Clash of the Titans and Olivier are both correct.
ShibbOleth, no it’s defintely Sally Kellerman, although I did have to check to make sure. James Earl Jones is wrong, I’m afraid.
Kyle MacLachlan, Michael Madsen, and Floyd Westerman in The Doors with Kathleen Quinlan
Tin Men is right, but not DeVito.
Both right.
Neve Campbell, John C McGinley, and Oliver Platt in Three to Tango with Matthew Paerry
Richard Dreyfus?
And finally, in the category of “How could I forget that?!?!”
Robert Duvall, Sally Kellerman, Tom Skerritt in MASH with Elliott Gould
Ok, we’re cooking with gas now.
An update:
Donal Logue/Ben Kingsley/River Pheonix - Sneakers - (not Poitier, Strathairn)
Amanda de Cadenet/Valeria Golino/Alicia Witt - Four Rooms
Andy Garcia/Sean Connery/Billy Drago - The Untouchables - (not De Niro)
Thora Birch/Benjamin Bratt/Harrison Ford - Clear & Present Danger - (not Dafoe, Jones)
Ursula Andress/Burgess Meredith/Maggie Smith - Clash of the Titans - Laurence Olivier
Barbara Hershey/Bruno Kirby/JT Walsh - Tin Men - Richard Dreyfuss
Kyle MacLachlan/Michael Madsen/Floyd Westerman - The Doors - Kathleen Quinlan
Neve Campbell/John C McGinley/Oliver Platt - Three To Tango - Matthew Perry
Robert Duvall/Sally “Hot Lips” Kellerman/Tom Skerritt - MASH - Elliot Gould
Doing well guys!
Although I’d love to guess Ted Raimi for Clear and Present Danger, I’ll go with Anne Archer
You can go ahead and guess both, but they’d both be wrong 
How 'bout Hope Lange then?
Salma Hayak, Four Rooms?
Sorry, no. But if you’re looking on the IMDB, you’re reasonably close…
Nope. I’ll give you a clue - this part is somewhat of an example of tdn’s ‘elegant’ answers.
Tim Roth, Four Rooms?