Kinda sorta here, but Charlie Day, of It’s Always Sunny in Philadelphia is real-life married to Mary Elizabeth Ellis, who plays his unreciprocated love interest, The Waitress, in the show.
Not just The Fly, of course. They were in Earth Girls are Easy and Transylvania 6-500 together, too.
Richard Benjamin and Paula Prentiss. They co-starred as a married couple in the 1960s TV series He and She, and appeared in the movies Catch-22, Saturday the 14th, No Room to Run, and Packin’ It In together.
Anna Paquin and Stephen Moyer on True Blood.
Ferris Buellers parents
Stana Katic and Nathan Fillion from Castle dated several years ago. Some think this has lead to the current weirdness in the show, with them not appearing together much (or even appearing in an episode at all). But they supposedly broke up in 2012 and the problem got bad only this season.
BTW, the Galecki/Cuoco thing is widely considered to have been fake. Much like Galecki/Gilbert.
Neat!!
Lea Michelle and Cory Monteith starred in *Glee *together as high school students (I stopped watching while her character was still merely pining for his but I suspect they hooked up?) Oddly enough, she had dated the guy who played the choir director before the show started.
If you recall, Monteith committed suicide in 2013, which must be totally fucking awful to deal with in the public eye (for Michelle).
Steve Martin and Bernadette Peters
Clint Eastwood and Sondra Locke
Clint Eastwood and Frances Fisher
Heh. I just realized you said on-screen couples. That makes my post quite icky.
Meredith Baxter & David Birney.
Michael J. Fox & Tracy Pollen
And from the soaps world: Bill Hayes and Susan Seaforth Hayes (Doug & Julie on Days of Our Lives)
Martin Freeman and Amanda Abbington as the Watsons in Sherlock.
Peter Lind Hayes and Mary Healy from the early days of TV. They did three series together.
Will Arnett and Amy Poehler played husband and wife (briefly) on Arrested Development, mirroring their real relationship.
Vivan Leigh played the mistress of her husband Lawrence Olivier in The Hamilton Woman.
Gena Rowlands has an affair with John Cassavetes in Minnie and Moskowitz
Jayne Mansfield and Mickey Hargitay in Will Success Spoil Rock Hunter? and *The Loves of *Hercules
Kurt Russell and Goldie Hawn in Overboard.
Robert Sterling and Anne Jeffreys, who played George and Marion Kerby on Topper. They met in Sterling’s Broadway debut, got married in 1951, and remained married until Sterling’s death in 2006.
If animation counts, Mike Farrell and Shelley Fabares, who are married, played Jonathan and Martha Kent in the animated Superman series.
Burt Reynolds and Sally Field
Troy Donahue and Suzanne Pleshette (in Rome Adventure)
Warren Beatty and I Don’t Have Time For The Rest Of This Post.
Same for Julia Roberts.
Uma Thurman and Ethan Hawke, who were a couple in Gattaca and RL.