Our mad quest for carcinogens

It seems like every time I open a newspaper or watch a nightly newscast, there’s a new article somewhere in it proclaiming that some substance may cause cancer.

Usually, the substance under scrutiny is either some new group of chemicals with a scary-souding name, like dioxins or polychlorobiphenyls, or an unpopular substance, like second-hand cigarette smoke. And usually, the evidence for this claim of carcinogeneity is spotty at best – a disease-cluster here, an experiment with laboratory rats there, or maybe an isolated population study showing a weak association (an association of less than 2:1) between the substance and a particular form of cancer. Scientifically speaking, we’d have to say that the jury is still out on the substance’s carcinogeneity, but the story appears in print anyway. Obviously, the threat of a new carcinogen makes for better news than a scientific shrug of the shoulders – but I don’t think that’s the whole story as to why such articles appear, nor even the main reason for it.

Cancer is an insidious disease that we still don’t know very much about. And, worse, it has moved up to being the number two killer in America, mostly thanks to the medical conquest of other diseases. It seems that this mad public-health quest to find new carcinogens under every rock is fuelled by the idea that we, the public, are looking for something or someone to blame for all that cancer. We need a well-defined enemy. And we’re taking it out on anything that might make even the tiniest differences in our chances of getting cancer.

If and when we ever stumble upon a real prevention or cure for cancer, these little environmental “carcinogens” are going to seem laughably petty. It will be as though, after having discovered penicillin, we were to look back on the history of pneumonia and see that we used to suspect soggy pets and factory smokestacks of giving us pneumonia because people exposed to these “risk” factors had a 28% better chance of contracting the disease. (Note: I don’t think soggy animal fur or chimney smoke were ever actually implicated as causative agents of pneumonia – but humor me, here.) It will, almost, be reminiscent of the way we blamed witches and black cats for the Bubonic Plague. It will be seen for the irrational grasping-at-straws that it is. And then, worse, once we really have conquered cancer, we’ll start blaming everything for causing heart disease, or for causing whatever other cause-of-death moves up to take cancer’s place.

So: Are we wasting our time and resources, and ousting promising new chemicals from the marketplace, by looking for even the slightest hint of carcinogeneity in everything new and unpopular? Or is the potential economic impact of our quest for carcinogens – in terms of the cost spent to hunt them down, the cost to the producers of the “demonized” substance, and the hidden cost to the public of spending so much of their time reading carcinogen news – a small price to pay for marginally decreasing everyone’s chances of getting cancer?

Just consider asbestos. Used for hundreds of years. It was everywhere. And boy, does it sure cause lung cancer. But this was not apparent until the issue was examined closely. Also Benzene. Same deal. Ditto radioactive material, early researchers used it like a playtoy. And they died of leukemia. So no, the search for carcinogens is not a mad quest. Do some people overreact to flimsy evidence? Certainly. Should we call off legitimate investigation as a result? Of course not.

Qadgop, MD

What I’d like to see is less of the ‘too much X causes cancer’ syndrome.

Too much X causes cancer? of course it does! that’s why it’s described as ‘too much’, honestly, would anyone ever say ‘just the right amount of salt is bad for you’?

Many years ago, here in Australia, a doctor used to frequently write to the daily papers. His argument was that the incidence of all forms of cancer had increased since WWII and the increase of background radiation it created.

May be rubbish but…

don’t ask wrote:

I assume you meant to type “created it,” not “it created.”

I’ve heard similar theories, usually from certified crackpots. The incidence of cancer has increased since WW2, and the background radiation levels have increased since WW2, therefore the increase in cancer was caused by the increase in background radiation. A classic post-hoc or cum-hoc fallacy. The incidence of divorce has also increased since WW2, but this doesn’t mean that divorce causes cancer.

Meanwhile, Qadgop the Mercotan wrote:

Really? Hundreds of years? Hmmm … lemme look that up…

<tracer types in “asbestos history” on Google>

Wow! You’re not kidding! The first hit I got was from the Wisconsin Department of Natural Resources, which says in part:

“Asbestos has been known to man for centuries and has been used in literally hundreds of products. Asbestos was used because it is strong, insulates well, and resists fire and corrosion. The ancient Greeks used asbestos in their cloth and the Romans used it in their building materials.”

<tracer emits a low whistle.> The ancient Greeks and Romans! That’s not just centuries, that’s two millennia! And yet, from the time of its discovery in the ancient world all the way up to the asbestos studies done in the 1960s, its adverse health effects were unknown. Sorta like how cigarettes were invented in, what, the early 1600s?, and yet smoking wasn’t linked (and linked strongly!) to lung cancer until a few decades ago.

I wonder … was this, perhaps, because cancer wasn’t all that major a health concern until the 20th century? I mean, when you could drop dead tomorrow from dysentary or pneumonia or a local war breaking out, I’d think cancer avoidance would be kinda low on your priority list.

One of the most interesting studies I’ve heard about (and I heard about it second hand so I don’t have a citation) examined the age-adjusted cancer rate and found that, although the overall cancer rate in the population is increasing, the cancer rate for people of any particular age has remained constant for the long historical period the study examined.

In other words, your average 20-year old, 40-year old, 60-year old or 80-year old would have the same chance of getting cancer as would the average 20-, 40-, 60- or 80-year old in the early 20th Century, but with the increased average life span of the population there are so many more 60- and 80-year olds still around to get cancer. Put more bluntly, cancer is getting more people because other diseases aren’t.

It does seem a little odd to me, now that I think about it, that plenty of people are getting their panties in a bunch over substances that allegedly increase your chance of getting cancer, but until very recently[SUP]1[/SUP], hardly anybody has been pointing fingers of blame at substances that allegedly increase your chance of getting heart disease. Considering that heart disease is the number one killer in America, while cancer comes limping in at number two, I’d think heart disease would be the basis of a lot more lawsuits and Federally-mandated warning labels and such.

[SUP]1)[/SUP] I say “until very recently” because there have been a few cases of health professionals who wanted to ban high-fat food because it increases the eater’s risk of heart disease, as shown in a rather biased article at http://www.guestchoice.com/0419_war_on_fat.html.

Yes, but heart disease is generally internal – smoking, eating, etc. Cancer comes from those horrible nasty chemicals that evil industrialists are exposing us to.

I reviewed a book last year, Cancer: The Evolutionary Legacy, that addresses some of the points about what “causes” cancer and what doesn’t. I also interviewed the author and talked to him about “cancer clusters.”

I agree with Billdo- most folks used to drop dead at an early age, thus avoiding many of the icky things we endure nowadays.

As Bill Maher used to say, “America causes cancer.”

“America causes cancer.” Heh. I hadn’t heard that Bill Maherism. “Americans, you’re just too darned affluent. Wallow around in the filth for a few decades and you’ll see cancer disappear overnight!”

Certainly one of the effects at work here is the press’s inability to put research into a scientific context.

As Quagdop says, there are good reasons to investigate the carcinogenic potential of the substances we surround ourselves with, because some of them are going to be real killers. However, this will naturally lead to a lot of borderline cases. The work that these researchers do relates to public health, so at some level it should be reported the public–to neglect to do so would be irresponsible.

However, the reporter, or his layman reader, can’t put this in the proper context. They hear that there’s a [numerical mumbo-jumbo] correlation between [sesquipedalian unprounouncable substance] and CANCER! Holy jeez! Cancer! They don’t have a good sense of where it fits into the spectrum of cancer-causing agents. They probably don’t have a very good idea of how much of it they, and their families, are exposed to. (I include myself as part of “they,” by the way.)

Similar things happen with every other science. Minor discoveries are blown out of proportion, major ones are misrepresented . . .

But you’re certainly on to something with the witches and black cats connection. Nobody likes the idea that our friends, loved ones, and we ourselves, can, for no good reason, get sick and die. We want logical reasons for why things happen to us, so that we can feel like we’re doing something to protect ourselves against them. If we can trick ourselves into believing that only people who offend the gods, live near power lines, or drink diet soda get cancer, then we can feel safer because we don’t do these things–or that we do only one out of three of the things. That gives us the illusion of power over our destiny.

Podkayne wrote:

And, unfortunately, neither do trial juries or members of Congress.

From the book review David B posted a link to:

"Greaves says the issue of ‘wanting to pin the blame on a villain’ is emotional and complex. Indeed, at the [Central Illinois Public Service Co.] trial, a defense attorney asked one mother of an afflicted child, ‘You simply do not accept the possibility that there is no cause for [your son’s] cancer, do you?’ The mother replied, ‘Somebody had done something to cause it.’ "
I used to enjoy reading The Junk Science Website, before I figured out how biased its reporting was. A certain “hidden URL” on that website, http://www.junkscience.com/sws.html, contains the entire text of Steve Malloy’s Science Without Sense: The Risky Business of Public Health Research. While this book is basically a slam at all public health research, it does make some good points about diease clusters, animal experiments that don’t mirror human exposure profiles, weak associations, and other questionable ways of showing that any unpopular substance you want to villify can be found to be a “risk factor” for causing cancer or other ailments.

tracer,

When I was doing the research for that book review, I found that quote from the trial and was actually amazed that none of the previous news coverage had really picked up on it. OK, I guess I shouldn’t have been amazed, but still…

… which leads to the next obvious news-media problem:

Even if it were absolutely proven, beyond a shadow of a doubt, that a substance once suspected of being a carcinogen is not, in fact, a carcinogen, this doesn’t make for very exciting news. “Scientists discover that saccharin doesn’t cause cancer in humans” just doesn’t make for good headlines.

Not a good headline, but something like saccharin they would probably report somewhere (like page 7 of the paper). If it were some lesser-known chemical, though, you’re right – they wouldn’t report it at all.

Indeed, that’s the problem. When somebody does a preliminary test with 10 rats and finds what appears to be a problem, it makes news all over the place. When others do follow-up tests with much larger sample populations and find nothing, it’s not reported.

In fact, Dr. Dean Edell wrote in one of his books that when he was doing TV reports out of a newsroom, they led into one of his by talking about a study of a very small number of rats who were found to have something wrong after eating genetically-modified potatoes (or something like that). Before he went into his segment, he turned to the newsman and said he hoped people would ignore that report. I like that guy! :smiley: