Pain Pill Hangover??

I haven’t taken a pain pill in many many years. I usually just deal with it. Last night the pain in my back was so severe I took some medication. A total of 3 ultums and one tylenol with codiene. Today I am drug out and feeling very weird. Could this be from the medication I took yesterday?

If you just feel crappy in general you’re probably still a bit buzzed from the meds. Ultram (at least for me, at least when I take that many at once) floats around in my system for a good 24 hours. Some caffeine the next day helps bring me back to normal. If, on the other hand, you have a headache, I’d call that a hangover, it’s essentially a rebound from the narcotics and the reason migraine docs very rarely prescribe them.

I am a little short on coffee today, no appetite either.

Withdrawal has been observed after a single dose of an opioid, such as morphine.

You took 3 “ultums” (I presume Ultram, the branded name for tramadol, as opposed to some ultimate strength tums formulation), which is argued to be roughly equipotent to 15mg of morphine if these were 50mg immediate-release tablets, and where the starting dose is normally 1 tablet, and combined it with another opioid, codeine, which if it was a Tylenol#3 would have been 30mg of codeine roughly equipotent to 9mg of morphine (assuming you aren’t a poor metabolizer or an ultrarapid metabolizer at 2D6, otherwise all bets are off since the mu-opioid receptor mitigated effects from both drugs depend on that pathway) for a rough total approximating 24mg of morphine, along with acute and withdrawal effects from tramadol at a higher than normal dosage on SERT (SErotonin Reuptake Transporter) and NET (Norepinephrine Reuptake Transporter). I’d say that yes, it’s is reasonable to suspect yesterday’s medication use as a cause of your present symptoms. Happily, if it is (predominately) due to opioid withdrawal effects, you shouldn’t be in any form of danger, and the effects should dissipate over the next few hours (if they haven’t already by the time you read this post).

For future back pain episodes, I suggest proactively working with a qualified healthcare professional to come up with a plan of attack less likely to leave you in this state. Despite how much it would simplify things if it were true, when it comes to drugs, particularly drugs used to relieve pain, more of one drug or another does not necessarily equal better.

I didn’t take them all at once, it was spread over about 4 hours. I am starting to feel a little better allready. The Dr had prescribed them to me for back pain a few years ago and I never took them then.

This didn’t take long:

Under Interactions:

codeine ↔ tramadol

Applies to:Tylenol with Codeine #3 (acetaminophen/codeine) and tramadol

Ask your doctor before using codeine and traMADol together. Using these medications together can increase your risk of seizures, breathing problems, and other side effects. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. Tell your doctor if you have weak or shallow breathing, tremors, restlessness, seizures, or problems with speech, balance, or walking. Avoid driving until you know how the medications will affect you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

See Tramadol and Tylenol with Codeine #3 Interactions - Drugs.com

You tripped on a nasty gotcha.

Don’t mix them again, 'K?

I rarely even do aspirin, so I likely have low tolerance. I guess I shouldn’t have mixed them.